Recognises mouse DNGR-1, also known as CLEC9A, which is a highly specific marker of the CD8a+ and the CD103+ DC subsets, as well as a receptor able to recognise a preformed signal exposed on necrotic cells.
| Institute |
|---|
| Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| Cat. #: | 151704 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Immunology;Stem cell biology |
| Application: | WB |
| Target: | Mouse DNGR1 |
| Reactivity: | Mouse |
| Clone: | 397 |
| Host: | Rat |
| Class: | Monoclonal |
| Alternate name: | C-Type Lectin Domain Family 9 Member A; HEEE9341; UNQ9341; DNGR-1; CD37; DNGR1 |
|---|---|
| Product description: | Recognises mouse DNGR-1, also known as CLEC9A, which is a highly specific marker of the CD8a+ and the CD103+ DC subsets, as well as a receptor able to recognise a preformed signal exposed on necrotic cells. |
| Conjugation: | Unconjugated |
| Isotype: | IgG2a |
| Immunogen: | RBL-2H3 cells expressing mouse DNGR-1 fused to an HA epitope |
| Myeloma used: | Y3.AG.1.2.3 |
| Target background: | Recognises mouse DNGR-1, also known as CLEC9A, which is a highly specific marker of the CD8a+ and the CD103+ DC subsets, as well as a receptor able to recognise a preformed signal exposed on necrotic cells. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Joffre et al. 2010. Eur J Immunol. 40(5):1255-65. PMID: 20333625. Efficient and versatile manipulation of the peripheral CD4+ T-cell compartment by antigen targeting to DNGR-1/CLEC9A. Sancho et al. 2009. Nature. 458(7240):899-903. PMID: 19219027. Identification of a dendritic cell receptor that couples sensing of necrosis to immunity. Sancho et al. 2008. J Clin Invest. 118(6):2098-110. PMID: 18497879. Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin. |
|---|
| Cat. # | Tool Name | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 151019 | Anti-Mos [S3.1] |
Key Info
Anti-Mos [S3.1]
|
View Tool | |||||||||||||||||||
| 151027 | Anti-HSVICP8 [10A3] |
Key Info
Anti-HSVICP8 [10A3]
|
View Tool | |||||||||||||||||||
| 151028 | Anti-Cytochrome P450 2C2, 2B1/2 [h7] |
Key Info
Anti-Cytochrome P450 2C2, 2B1/2 [h7]
|
View Tool | |||||||||||||||||||
| 151036 | Anti-ICAM1 [15.2] |
Key Info
Anti-ICAM1 [15.2]
|
View Tool | |||||||||||||||||||
| 151039 | Anti-Integrin aVb3 [23C6] |
Key Info
Anti-Integrin aVb3 [23C6]
|
View Tool | |||||||||||||||||||
Please note we may take up to three days to respond to your enquiry.
CancerTools.org uses the contact information provided to respond to you about our research tools and service. For more information please review our privacy policy.