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#154730

Anti-CD49F (Integrin Alpha 6) [GoH3]

Cat. #154730

Anti-CD49F (Integrin Alpha 6) [GoH3]

Cat. #: 154730

Sub-type: Primary antibody

Unit size: 100 ug

Availability: 3-4 weeks

Target: CD49F

Class: Monoclonal

Application: FACS ; IHC ; IP

Reactivity: Dog ; Human ; Mouse

Host: Rat

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Arnoud Sonnenberg

Institute: Netherlands Cancer Institute

Tool Details
Target Details
Applications
Handling
References

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

  • Name: Anti-CD49F (Integrin Alpha 6) [GoH3]
  • Alternate name: ITGA6
  • Research fields: Immunology
  • Tool sub type: Primary antibody
  • Class: Monoclonal
  • Conjugation: Unconjugated
  • Molecular weight: 126 kDa
  • Strain: Balb/c
  • Reactivity: Dog ; Human ; Mouse
  • Host: Rat
  • Application: FACS ; IHC ; IP
  • Description: The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Specific loss of this integrin chain in the intestinal epithelium, and thus of their hemidesmosomes, induces long-standing colitis and infiltrating adenocarcinomas.
  • Immunogen: 1242-1255 of the C-terminus of the Human c-erbB-2/HER-2/neu protein. This sequence is identical in Rat neu
  • Isotype: IgG2a
  • Myeloma used: Sp2/0-Ag14

Target Details

  • Target: CD49F
  • Molecular weight: 126 kDa
  • Target background: The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Specific loss of this integrin chain in the intestinal epithelium, and thus of their hemidesmosomes, induces long-standing colitis and infiltrating adenocarcinomas.

Applications

  • Application: FACS ; IHC ; IP

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Unit size: 100 ug
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15° C to -25° C
  • Shipping conditions: Dry ice

References

  • Yoshino et al. 2000. Exp Anim. 49(2):97-110. PMID: 10889948.
  • Upgrading of flow cytometric analysis for absolute counts, cytokines and other antigenic molecules of cynomolgus monkeys (Macaca fascicularis) by using anti-human cross-reactive antibodies.
  • Galkowska et al. 1996. Vet Immunol Immunopathol. 53(3-4):329-34. PMID: 8969052.
  • Ticchioni et al. 1995. J Immunol. 154(3):1207-15. PMID: 7529794.

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