Anti-CD44v3 [2C5]

Monoclonal antibody which binds all isoforms of CD44.

Contributors

Institute
University of Oxford
Cat. #: 151572
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cancer;Cell biology;Cell signaling and signal transduction;Immunology
Application: FACS ; IHC ; IP ; WB
Target: CD44v3-10-Fc
Reactivity: Human
Clone: 2C5
Host: Mouse
Class: Monoclonal
Alternate name: CD44 Molecule; Hematopoietic Cell E- And L-Selectin Ligand; GP9 Lymphocyte Homing/Adhesion Receptor; Chondroitin Sulfate Proteoglycan 8; Extracellular Matrix Receptor III; Heparan Sulfate Proteoglycan; Phagocytic Glycoprotein; Hyaluronate Receptor; Hermes Antigen; ECMR-III; HUTCH-I; Epican; CDW44; MDU2; MDU3; MIC4; LHR; Cell Surface Glycoprotein CD44; Phagocytic Glycoprotein I; Soluble CD44; CSPG8; HCELL; PGP-1; MC56; Pgp1
Product description: Monoclonal antibody which binds all isoforms of CD44.
Conjugation: Unconjugated
Isotype: IgG2a
Immunogen: Human chimeric fusion protein
Immunogen Uniprot ID: P16070
Target background: CD44H, also called CD44s, refers to the standard form of CD44 without variable exons. A large number of CD44 isoforms can be generated by the insertion of different combinations of at least nine exons. CD44 is an integral cell membrane glycoprotein that binds to hyaluronan and is involved in matrix adhesion, lymphocyte activation, and lymph node homing. The CD44 protein is expressed as a family of molecular isoforms generated from alternative RNA splicing and posttranslational modifications. CD44 is expressed on multiple cell types and is involved in multiple functions including cell-cell interactions and cell-extracellular matrix binding. CD44 participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, haematopoiesis, and tumour metastasis. Hyaluronan, a high molecular weight polysaccharide component of the extracellular matrix acts as the principal ligand for the CD44 receptor.
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: Store at -20° C frozen. Avoid repeated freeze / thaw cycles
Shipping conditions: Dry ice
References:

Nagano et al. 2004. Cancer Sci. 95(12):930-5. PMID: 15596040.

Lynch et al. 2004. Nat Rev Immunol. 4(12):931-40. PMID: 15573128.

Consequences of regulated pre-mRNA splicing in the immune system.

Mechanism and biological significance of CD44 cleavage.

Murakami et al. 2003. Oncogene. 22(10):1511-6. PMID: 12629514.

Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44.

Ponta et al. 2003. Nat Rev Mol Cell Biol. 4(1):33-45. PMID: 12511867.

CD44: from adhesion molecules to signalling regulators.

Yu et al. 1996. J Biol Chem. 271(34):20603-7. PMID: 8702806.

A new alternatively spliced exon between v9 and v10 provides a molecular basis for synthesis of soluble CD44.

Fox et al. 1994. Cancer Res. 54(16):4539-46. PMID: 7519124.

Normal human tissues, in addition to some tumors, express multiple different CD44 isoforms.

Screaton et al. 1992. Proc Natl Acad Sci U S A. 89(24):12160-4. PMID: 1465456.

Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons.

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