Cat. #152690
Anti-CD13 [22A5] mAb
Cat. #: 152690
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 3-4 weeks
Target: Aminopeptidase N (CD13)
Class: Monoclonal
Application: FACS ; IHC ; IP
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Mike Horton
Institute: Queen Mary University of London
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-CD13 [22A5] mAb
- Alternate name: Alanyl Aminopeptidase; Membrane; Microsomal Aminopeptidase; Aminopeptidase M; Myeloid Plasma Membrane Glycoprotein CD13; GP15; CD13; PEPN
- Research fields: Biochemistry;Cancer;Cell biology;Metabolism;Stem cell biology
- Clone: 22A5
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Strain: Balb/c
- Reactivity: Human
- Host: Mouse
- Application: FACS ; IHC ; IP
- Description: Aminopeptidase N (CD13) is a cell-surface metalloprotease involved in the metabolism of regulatory peptides. 22A5 may be useful for the diagnosis and immunophenotyping of leukaemia.
- Immunogen: A cell suspension containing osteoclasts from osteoclastomas.
- Isotype: IgG2a kappa
- Recommended controls: Cells of myelomonocytic lineage
Target Details
- Target: Aminopeptidase N (CD13)
- Tissue cell line specificity: Cells of myelomonocytic lineage
- Target background: Aminopeptidase N (CD13) is a cell-surface metalloprotease involved in the metabolism of regulatory peptides. 22A5 may be useful for the diagnosis and immunophenotyping of leukaemia.
Applications
- Application: FACS ; IHC ; IP
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Dry ice
References
- Murray et al. 1995. Leuk Lymphoma. 17(5-6):501-8. PMID: 7549844.
- Immunocytochemical studies of an antigen in a human T-cell lymphoma line (Jurkat) recognized by certain monoclonal antibodies to CD-13 (aminopeptidase-N).
- van Hal et al. 1994. J Immunol. 153(6):2718-28. PMID: 7915741.
- Potential indirect anti-inflammatory effects of IL-4. Stimulation of human monocytes, macrophages, and endothelial cells by IL-4 increases aminopeptidase-N activity (CD13
- EC 3.4.11.2).
- Ashmun et al. 1990. Blood. 75(2):462-9. PMID: 1967220.
- Metalloprotease activity of CD13/aminopeptidase N on the surface of human myeloid cells.
- Look et al. 1989. J Clin Invest. 83(4):1299-307. PMID: 2564851.
- Human myeloid plasma membrane glycoprotein CD13 (gp150) is identical to aminopeptidase N.
- Horton et al. 1985. Cancer Res. 45(11 Pt 2):5663-9. PMID: 4053038.
- Monoclonal antibodies to osteoclastomas (giant cell bone tumors): definition of osteoclast-specific cellular antigens.
