Aminopeptidase N (CD13) is a cell-surface metalloprotease involved in the metabolism of regulatory peptides. 22A5 may be useful for the diagnosis and immunophenotyping of leukaemia.
| Inventor | Institute |
|---|---|
| Mike Horton | Queen Mary University of London |
| Cat. #: | 152690 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Biochemistry;Cancer;Cell biology;Metabolism;Stem cell biology |
| Application: | FACS ; IHC ; IP |
| Target: | Aminopeptidase N (CD13) |
| Reactivity: | Human |
| Clone: | 22A5 |
| Host: | Mouse |
| Class: | Monoclonal |
| Primary citation: | Horton et al. 1985. Cancer Res. 45(11 Pt 2):5663-9. PMID: 4053038. |
| Alternate name: | Alanyl Aminopeptidase; Membrane; Microsomal Aminopeptidase; Aminopeptidase M; Myeloid Plasma Membrane Glycoprotein CD13; GP15; CD13; PEPN |
|---|---|
| Product description: | Aminopeptidase N (CD13) is a cell-surface metalloprotease involved in the metabolism of regulatory peptides. 22A5 may be useful for the diagnosis and immunophenotyping of leukaemia. |
| Conjugation: | Unconjugated |
| Isotype: | IgG2a kappa |
| Immunogen: | A cell suspension containing osteoclasts from osteoclastomas. |
| Target background: | Aminopeptidase N (CD13) is a cell-surface metalloprotease involved in the metabolism of regulatory peptides. 22A5 may be useful for the diagnosis and immunophenotyping of leukaemia. |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Murray et al. 1995. Leuk Lymphoma. 17(5-6):501-8. PMID: 7549844. Immunocytochemical studies of an antigen in a human T-cell lymphoma line (Jurkat) recognized by certain monoclonal antibodies to CD-13 (aminopeptidase-N). van Hal et al. 1994. J Immunol. 153(6):2718-28. PMID: 7915741. Potential indirect anti-inflammatory effects of IL-4. Stimulation of human monocytes, macrophages, and endothelial cells by IL-4 increases aminopeptidase-N activity (CD13 EC 3.4.11.2). Ashmun et al. 1990. Blood. 75(2):462-9. PMID: 1967220. Metalloprotease activity of CD13/aminopeptidase N on the surface of human myeloid cells. Look et al. 1989. J Clin Invest. 83(4):1299-307. PMID: 2564851. Human myeloid plasma membrane glycoprotein CD13 (gp150) is identical to aminopeptidase N. Horton et al. 1985. Cancer Res. 45(11 Pt 2):5663-9. PMID: 4053038. Monoclonal antibodies to osteoclastomas (giant cell bone tumors): definition of osteoclast-specific cellular antigens. |
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