#152690

Anti-CD13 [22A5] mAb

Cat. #152690

Anti-CD13 [22A5] mAb

Cat. #: 152690

Sub-type: Primary antibody

Unit size: 100 ug

Availability: 3-5 days

Target: Aminopeptidase N (CD13)

Class: Monoclonal

Application: FACS ; IHC ; IP

Reactivity: Human

Host: Mouse

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Mike Horton

Institute: Queen Mary University of London

Tool Details
Target Details
Applications
Handling
References

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

  • Name: Anti-CD13 [22A5] mAb
  • Alternate name: Alanyl Aminopeptidase; Membrane; Microsomal Aminopeptidase; Aminopeptidase M; Myeloid Plasma Membrane Glycoprotein CD13; GP15; CD13; PEPN
  • Research fields: Biochemistry;Cancer;Cell biology;Metabolism;Stem cell biology
  • Clone: 22A5
  • Tool sub type: Primary antibody
  • Class: Monoclonal
  • Conjugation: Unconjugated
  • Strain: Balb/c
  • Reactivity: Human
  • Host: Mouse
  • Application: FACS ; IHC ; IP
  • Description: Aminopeptidase N (CD13) is a cell-surface metalloprotease involved in the metabolism of regulatory peptides. 22A5 may be useful for the diagnosis and immunophenotyping of leukaemia.
  • Immunogen: A cell suspension containing osteoclasts from osteoclastomas.
  • Isotype: IgG2a kappa
  • Recommended controls: Cells of myelomonocytic lineage

Target Details

  • Target: Aminopeptidase N (CD13)
  • Tissue cell line specificity: Cells of myelomonocytic lineage
  • Target background: Aminopeptidase N (CD13) is a cell-surface metalloprotease involved in the metabolism of regulatory peptides. 22A5 may be useful for the diagnosis and immunophenotyping of leukaemia.

Applications

  • Application: FACS ; IHC ; IP

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Unit size: 100 ug
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15° C to -25° C
  • Shipping conditions: Shipping at 4° C

References

  • Murray et al. 1995. Leuk Lymphoma. 17(5-6):501-8. PMID: 7549844.
  • Immunocytochemical studies of an antigen in a human T-cell lymphoma line (Jurkat) recognized by certain monoclonal antibodies to CD-13 (aminopeptidase-N).
  • van Hal et al. 1994. J Immunol. 153(6):2718-28. PMID: 7915741.
  • Potential indirect anti-inflammatory effects of IL-4. Stimulation of human monocytes, macrophages, and endothelial cells by IL-4 increases aminopeptidase-N activity (CD13
  • EC 3.4.11.2).
  • Ashmun et al. 1990. Blood. 75(2):462-9. PMID: 1967220.
  • Metalloprotease activity of CD13/aminopeptidase N on the surface of human myeloid cells.
  • Look et al. 1989. J Clin Invest. 83(4):1299-307. PMID: 2564851.
  • Human myeloid plasma membrane glycoprotein CD13 (gp150) is identical to aminopeptidase N.
  • Horton et al. 1985. Cancer Res. 45(11 Pt 2):5663-9. PMID: 4053038.
  • Monoclonal antibodies to osteoclastomas (giant cell bone tumors): definition of osteoclast-specific cellular antigens.