Cat. #155248
Anti-CD-45 [C455.1F]
Cat. #: 155248
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 3-4 weeks
Target: CD45
Class: Monoclonal
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Institute: Yale University
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-CD-45 [C455.1F]
- Cancer: Blood cancer
- Cancers detailed: Leukemia/Lymphoma
- Research fields: Immunology
- Tool sub type: Primary antibody
- Class: Monoclonal
- Purpose: Marker
- Conjugation: Unconjugated
- Description: Monoclonal antibody which binds to an epitope within exon C of CD45. Background and Research Application CD45RC, or PTPRC, is a protein tyrosine-protein phosphatase required for T cell activation through the antigen receptor. CD45 regulates Src-family kinases, integrin-mediated signal transduction pathways and can suppress JAK kinases, acting as a negative regulator of cytokine receptor signalling. Upon T cell activation, CD45RC recruits and dephosphorylates SKAP1 and FYN. Mutations of the g...
- Immunogen: P06800
- Immunogen uniprot id: P06800
- Isotype: IgG2a kappa
Target Details
- Target: CD45
- Target background: Monoclonal antibody which binds to an epitope within exon C of CD45. Background and Research Application CD45RC, or PTPRC, is a protein tyrosine-protein phosphatase required for T cell activation through the antigen receptor. CD45 regulates Src-family kinases, integrin-mediated signal transduction pathways and can suppress JAK kinases, acting as a negative regulator of cytokine receptor signalling. Upon T cell activation, CD45RC recruits and dephosphorylates SKAP1 and FYN. Mutations of the ...
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: Store at -20° C frozen. Avoid repeated freeze / thaw cycles
- Shipping conditions: Shipping at 4° C
References
- Bottomly et al. 1989. Eur J Immunol. 19(4):617-23. PMID: 2567241.
