Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherins are known to be involved in cell migration. Changes in cadherin expression can be involved in the metastasis of cancerous cells impacting the stage, grade […]
| Inventor | Institute |
|---|---|
| Jack A Schalken | Radboud University Medical Center (UMC) |
| Cat. #: | 160534 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Cell biology |
| Application: | WB |
| Target: | Extracellular domain of cadherin-11 |
| Reactivity: | Human |
| Class: | Monoclonal |
| Alternate name: | CDH11, Cadherin 11, Cadherin-11 |
|---|---|
| Product description: | Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherins are known to be involved in cell migration. Changes in cadherin expression can be involved in the metastasis of cancerous cells impacting the stage, grade and prognosis of carcinomas. |
| Conjugation: | Unconjugated |
| Immunogen: | Glutathione-S-transferase (GST) fusion protein of the extracellular domain of cadherin-11 |
| Myeloma used: | Sp2/0 |
| Target background: | Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherins are known to be involved in cell migration. Changes in cadherin expression can be involved in the metastasis of cancerous cells impacting the stage, grade and prognosis of carcinomas. |
|---|
| Format: | Liquid |
|---|---|
| Shipping conditions: | Dry ice |
| References: |
Tomita et al. 2000. Cancer Res. 60(13):3650-4. PMID: 10910081. Bussemakers et al. 2000. Int J Cancer. 85(3):446-50. PMID: 10652439. |
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