Cat. #151062
Anti-BCRABL [7c6] mAb
Cat. #: 151062
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 3-4 weeks
Target: BCRABL
Class: Monoclonal
Application: IF ; IP ; WB
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Susheela Dhut
Institute: Queen Mary University of London
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-BCRABL [7c6] mAb
- Alternate name: Cell division control protein 13; YDL22C
- Research fields: Cancer;Cell signaling and signal transduction;Genetics
- Clone: 7c6
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Molecular weight: 210 kDa
- Strain: Balb/c
- Reactivity: Human
- Host: Mouse
- Application: IF ; IP ; WB
- Description: Monoclonal antibody directed against BCR-ABL oncoprotein.
- Immunogen: Bcr686 thyroglobulin conjugate
- Immunogen uniprot id: Q62199
- Isotype: IgG2a
- Myeloma used: P3X63Ag8
Target Details
- Target: BCRABL
- Molecular weight: 210 kDa
- Target background: The BCR gene is involved in the 9:22 translocation that generates the Philadelphia chromosome both in chronic myeloid leukaemia (CML) and in a proportion of cases of acute lymphocytic leukaemia (ALL). A 5' bcr sequence becomes fused to an abl sequence (including tyrosine kinase domain sequences) from chromosome 9. This results in the production of a chimeric BCR-ABL oncoprotein with constitutively active tyrosine kinase activity. Anti-BCRABL antibody may be useful for studies of the oncogene and have potential diagnostic and prognostic applications, particularly within leukaemia. This antibody is specific for the SSINEEITPRRQS epitope of BCR (residues 686-696), and as such is able to recognise full-length BCR and the p210 form of the BCR-ABL fusion protein.
Applications
- Application: IF ; IP ; WB
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: Store at -20° C frozen. Avoid repeated freeze / thaw cycles
- Shipping conditions: Shipping at 4° C
Related Tools
- Related tools: Anti-BCRABL, Recombinant [7c6]
References
- Mallery et al. 2017. Cancer Prev Res (Phila). 10(1):76-88. PMID: 27756753.
- Dhut et al. 1990. Leukemia. 4(11):745-50. PMID: 2232885.
- BCR-ABL and BCR proteins: biochemical characterization and localization.
- Dhut et al. 1988. Oncogene. 3(5):561-6. PMID: 3078961.
- Identification of two normal bcr gene products in the cytoplasm.
- Walker et al. 1987. Nature. 329(6142):851-3. PMID: 3478595.
- Novel chimaeric protein expressed in Philadelphia positive acute lymphoblastic leukaemia.
