Monoclonal antibody which detects a commonly mutated telomere regulator.
| Inventor | Institute |
|---|---|
| Helen Turley | University of Oxford |
| Cat. #: | 151887 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Cell biology;Genetics |
| Application: | IHC ; IF ; WB |
| Target: | ATRX |
| Reactivity: | Human ; Mouse |
| Clone: | 23c |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | RAD54, XNP |
|---|---|
| Product description: | Monoclonal antibody which detects a commonly mutated telomere regulator. |
| Conjugation: | Unconjugated |
| Isotype: | IgG3 kappa |
| Immunogen: | Recombinant Protein |
| Immunogen Uniprot ID: | P46100 |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Target background: | ATRX is a transcriptional regulator which is required for deposition of the histone variant H3.3 at telomeres and other genomic repeats. This is important to maintain silencing at these sites. ATRX mutations are associated with an X-linked mental retardation (XLMR) syndrome ATRX is commonly mutated in cancers which maintain their telomeres by a telomerase independent pathway. This generates alternative lengthening of telomeres. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | Store at -20° C frozen. Avoid repeated freeze / thaw cycles |
| Shipping conditions: | Dry ice |
| References: |
Cooper et al. 2016. Nat Commun. 7:13661. PMID: 27892467. Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2. McDowell et al. 1999. Proc Natl Acad Sci U S A. 96(24):13983-8. PMID: 10570185. Localization of a putative transcriptional regulator (ATRX) at pericentromeric heterochromatin and the short arms of acrocentric chromosomes. |
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