Monoclonal antibody directed against 5T4, with use as a prognostic aid of tumours.
| Inventor | Institute |
|---|---|
| Peter Stern | Cancer Research UK, Manchester Institute |
| Cat. #: | 152711 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Stem cell biology |
| Application: | ELISA ; FACS ; IF ; Fn ; WB |
| Target: | 5T4 oncofetal glycoprotein |
| Reactivity: | Mouse |
| Clone: | B3F1 |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | Trophoblast Glycoprotein; 5T4 Oncofetal Trophoblast Glycoprotein; Wnt-Activated Inhibitory Factor 1; 5T4 Oncotrophoblast Glycoprotein; 5T4 Oncofetal Antigen; WAIF1; M6P1; 5T4; 5T4AG |
|---|---|
| Product description: | Monoclonal antibody directed against 5T4, with use as a prognostic aid of tumours. Background and Research Application The murine 5T4 monoclonal antibody, clone B3F1, identifies the human 5T4 oncofoetal antigen, also known as trophoblast glycoprotein. 5T4 is a highly glycosylated protein expressed by trophoblast and a few specialized adult epithelia and is an antagonist of the Wnt/ ?-catenin signalling pathway. Up-regulation of 5T4 expression in some cancers is associated with poor clinical outcome; overexpression of human 5T4 cDNA in epithelial cells can alter their morphology and motility, supporting a role for such functions in cancer and development. 5T4 has limited expression in normal tissues, but is widespread in tumours, thus its expression is used as a prognostic aid. 5T4 is typically found in colorectal, ovarian and gastric tumours. 5T4 is a potential target for T cells, in antibody-directed immunotherapy. |
| Conjugation: | Unconjugated |
| Isotype: | IgG2a |
| Molecular weight: | 46.5 kDa |
| Immunogen: | Q9Z0L0 |
| Immunogen Uniprot ID: | Q9Z0L0 |
| Target background: | Monoclonal antibody directed against 5T4, with use as a prognostic aid of tumours. Background and Research Application The murine 5T4 monoclonal antibody, clone B3F1, identifies the human 5T4 oncofoetal antigen, also known as trophoblast glycoprotein. 5T4 is a highly glycosylated protein expressed by trophoblast and a few specialized adult epithelia and is an antagonist of the Wnt/ ?-catenin signalling pathway. Up-regulation of 5T4 expression in some cancers is associated with poor clinical outcome; overexpression of human 5T4 cDNA in epithelial cells can alter their morphology and motility, supporting a role for such functions in cancer and development. 5T4 has limited expression in normal tissues, but is widespread in tumours, thus its expression is used as a prognostic aid. 5T4 is typically found in colorectal, ovarian and gastric tumours. 5T4 is a potential target for T cells, in antibody-directed immunotherapy. |
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| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | Store at -20° C frozen. Avoid repeated freeze / thaw cycles |
| Shipping conditions: | Dry ice |
| References: |
Castro et al. 2012. Cancer Immunol Immunother. 61(7):1005-18. PMID: 22127365. Southgate et al. 2010. PLoS One. 5(4):e9982. PMID: 20376365. CXCR4 mediated chemotaxis is regulated by 5T4 oncofetal glycoprotein in mouse embryonic cells. Ward et al. 2003. J Cell Sci. 116(Pt 22):4533-42. PMID: 14576347. The 5T4 oncofoetal antigen is an early differentiation marker of mouse ES cells and its absence is a useful means to assess pluripotency. Woods et al. 2002. Biochem J. 366(Pt 1):353-65. PMID: 12003637. Characterization of the murine 5T4 oncofoetal antigen: a target for immunotherapy in cancer. |
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