![TR146 Cell Line. 3 days post plating. Image courtesy of the European Collection of Authenticated Cell Cultures (ECACC)](https://cancertools.org/wp-content/uploads/caafd1cf-5d3f-4cbf-9a6c-80af355f664d-1.jpg)
TR146 Cell Line Product
Cell line to investigate buccal mucosa, and as a model for absorption and metabolism of various substances and enzymatically labile drugs.
Cell line to investigate buccal mucosa, and as a model for absorption and metabolism of various substances and enzymatically labile drugs.
Established from a squamous cell carcinoma (SCC) of the buccal mucosa (20mm-40mm) of a male patient, age 84. STNMP stage II, well differentiated, node positive tumour.
[…] line derived from a squamous cell carcinoma of the tongue of a Caucasian female. Keratin and involucrin markers present. Known mutations: p53 and p16. Cells are tumourigenic in athymic mice. […]
This cell line is highly responsive to TGF beta and undergoes epithelial to mesenchymal transition. It expresses high levels of TGF beta1. Fahey et al (1996).
The degree of dysplasia in the patient was described as mild to moderate. The cells show some stratification in confluent cultures and contain a keratin profile similar to the original dysplasia.
Adherent keratinocyte cell line derived from a lymph node metastasis squamous cell carcinoma (SSC) of the larynx. Keratin and involucrin markers present.
Adherent keratinocyte cell line derived from a squamous cell carcinoma of the hypopharynx of a Caucasian male.
[…] STNMP stage III, well differentiated, node positive tumour. Mutant p53, codon 266 exon 8, G to T; wild type K-, N-, and Ha-ras. This cell line is highly responsive to TGFbeta.
[…] line derived from a squamous cell carcinoma of the tongue of a Caucasian male. Keratin and involucrin markers present. Known mutations: p53, p16 and p14ARF. Cells are tumourigenic in athymic […]
Adherent cell line derived from a lymph node metastasis squamous cell carcinoma of the tongue of a Caucasian male. Keratin and involucrin markers present.
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