Cat. #157681
The Kinase Chemogenomic Set (KCGS)
Cat. #: 157681
Unit size: 1 plate
Availability: 10-12 Weeks
Application: The Kinase Chemogenomic Set (KCGS) can be used to study the biology of dark kinases from the human genome and uncover new molecular targets for drug discovery.
£2,700.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Tim Willson
Institute: The University of North Carolina at Chapel Hill ; Structural Genomics Consortium (SGC)
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Tool name: The Kinase Chemogenomic Set (KCGS)
- Research fields: Cancer
- Primary target: The list of kinases covered by the inhibitors in KCGS v1.0 and v2.0 can be found in the documentation section.
- Description: The Kinase Chemogenomic Set v2.0 (KCGS) is a collection of narrow-spectrum, small molecule kinase inhibitors assembled by the SGC-UNC to study the biology of understudied (“dark”) kinases. It is one of the most diverse and highly annotated, publicly available collections of kinase inhibitors. Version 2.0 builds on the original set and includes more than 280 compounds covering over 250 human kinases, providing researchers with a powerful resource for phenotypic screening and kinase biology studies. KCGS helps identify medically important kinases and supports the development of high-quality chemical probes for high-priority dark kinases of therapeutic interest. Dark kinases are those which are difficult to characterize, have limited biological information, and whose medical potential remains largely unexplored. The goal of KCGS is to generate, systematize, and disseminate knowledge about dark kinases, the biological networks in which they function, and their connections to cellular phenotypes and human disease.
- Application: The Kinase Chemogenomic Set (KCGS) can be used to study the biology of dark kinases from the human genome and uncover new molecular targets for drug discovery.
- Additional notes: Each inhibitor has been screened across hundreds of kinases and only those meeting strict selective criteria are included in the set. For more information on KCGS or for commonly asked questions, please visit https://www.sgc-unc.org/faq.
Handling
- Storage conditions: -80° C
- Shipping conditions: Dry Ice
Target Details
- Primary target: The list of kinases covered by the inhibitors in KCGS v1.0 and v2.0 can be found in the documentation section.
Application Details
- Application: The Kinase Chemogenomic Set (KCGS) can be used to study the biology of dark kinases from the human genome and uncover new molecular targets for drug discovery.
References
- Burdova et al. 2019. EMBO J. 38(20):e101443. PMID: 31424118.
- Wells et al. 2018. Medchemcomm. 9(1):44-66. PMID: 30108900.
- Drewry et al. 2017. PLoS One. 12(8):e0181585. PMID: 28767711.
