#153939

Fluorescent probe for Copper

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Cat. #153939

Fluorescent probe for Copper

Cat. #: 153939

Sub-type: Fluorescent Probe

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Application: determination of Cu(I) binding affinities of proteins and small-molecule ligands

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Contributor

Inventor: Christoph J. Fahrni

Institute: Georgia Institute Of Technology

Tool Details
Application Details
References

Tool Details

*FOR RESEARCH USE ONLY

  • Tool name: Fluorescent probe for Copper
  • Research fields: Drug development;Other
  • Tool sub type: Fluorescent Probe
  • Description: Copper is an essential trace element that is central to a broad range of biological processes, including cellular respiration, connective tissue formation, pigment synthesis, antioxidant defense, and photosynthesis in plants and bacteria. The measurement of reliable Cu(I) protein binding affinities requires competing reference ligands with similar binding strengths; however, the literature on such reference ligands is not only sparse but often conflicting. Here, Dr. Farhrni has designed a water-solube fluorescence probe for the detection of aqueous Cu(I). This probe has a high selectivity (57-fold) for Cu(I) compared to other cations such as Cu(II), Hg(II), and Cd(II).
  • Application: determination of Cu(I) binding affinities of proteins and small-molecule ligands
  • Solubility: water

Application Details

  • Application: determination of Cu(I) binding affinities of proteins and small-molecule ligands

References

  • Morgan et al. 2013. Dalton Trans. 42(9):3240-8. PMID: 23169532.
  • High-contrast fluorescence sensing of aqueous Cu(I) with triarylpyrazoline probes: dissecting the roles of ligand donor strength and excited state proton transfer.