Cat. #161687

Carbazole derivative HV-107

Cat. #: 161687

Availability: 3-4 weeks

Application: Cancer research, anti-metastatic therapeutics development, potential treatment for other hyperproliferative diseases associated with Rac1 and Cdc42

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

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Contributor

Inventor: Cornelis Vlaar

Institute: University of Puerto Rico

Primary Citation: Vlaar et al. Bioorg Med Chem. 26(4): 884-890 PMID: 29358027

Tool Details

Target Details

Application Details

References

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

Tool name: Carbazole derivative HV-107
Research fields: Cancer
Primary target: Rac
Secondary targets: Rac 1
Description: Carbazole derivative HV-107 is a highly potent novel anti-cancer and anti-metastatic carbazole derivative. Carbozole derivatives based on EHop-016 generated to mimic the ‘U-shaped’ conformation adopted by EHop-016 as it binds Rac1.
Application: Cancer research, anti-metastatic therapeutics development, potential treatment for other hyperproliferative diseases associated with Rac1 and Cdc42
Purpose: Designed to mimic the 'U-shaped' conformation adopted by EHop-016 as it binds Rac1

Target Details

Primary target: Rac
Secondary targets: Rac 1
Ic50: 250 nM

Application Details

Application: Cancer research, anti-metastatic therapeutics development, potential treatment for other hyperproliferative diseases associated with Rac1 and Cdc42

References

Vlaar et al. Bioorg Med Chem. 26(4): 884-890 PMID: 29358027