Cat. #162163
Recombinant Human CD155 Protein
Cat. #: 162163
Availability: Please enquire for quantities and pricing
Target: CD155-Fc. Human CD155 (aka PVR)
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Geraldine Mulley; Ian Jones
Institute: University of Reading
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Tool name: Recombinant Human CD155 Protein
- Research fields: Cell biology
- Source: Human
- Disease: Polio
- Target: CD155-Fc. Human CD155 (aka PVR)
- Description: Recombinant human CD155-Fc protein. Residues 28-328 fused to the Fc region of Human IgG1 and His tagged at the C-terminus. Purified from the supernatant by a combination of lectin chromatography and IMAC.
- Tag: Terminal 6xHis
- Expression system: Insect
- Uniprot id: P15151
Handling
- Purity: >90%
- Storage conditions: -20°C or less
- Storage buffer: PBS, 5% glycerol
- Shipping conditions: Frozen
Target Details
- Target: CD155-Fc. Human CD155 (aka PVR)
- Target background: Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytotoxicity of activated NK cells. Also acts a a virus receptor for many viruses including polio
