Anti-GTP [2A4] Product
Ras GTPases are frequently mutated in cancer and so far only few experimental inhibitors exist.
Anti-Rab11a [STo 2F3] Product
Rab11a is a member of the Rab family of Ras-like small GTPases, which regulate membrane trafficking events (e.g. vesicle recycling).
Raf-1FF/FF knockin mouse Product
A knockin of inactive Raf-1FF/FF mutant; can be use for in vivo study of inactive Raf-1 mutant, and Ras signalling;
Raf KI D486A Mouse Product
Knockin of oncogenic Raf-1D486A; in vivo study of oncogenic Raf-1 mutant, and Ras signalling
BDP-9066 MRCK Small Molecule Inhibitor Product
[…] organotypic model were dependent on MRCK signalling. Elevated MRCK? expression was reported to contribute to Ras oncogene-driven SCC development in genetically-modified mice following repression of the Notch 1 tumour suppressor. […]
BDP-8900 MRCK Small Molecule Inhibitor Product
[…] organotypic model were dependent on MRCK signalling. Elevated MRCKÃŽË› expression was reported to contribute to Ras oncogene-driven SCC development in genetically-modified mice following repression of the Notch 1 tumour suppressor. […]
H314 Cell Line Product
[…] to T and 373 exon 11, A to G; wild type K-, N- and Ha- ras. Tumourigenic in athymic nude mice on subcutaneous injection; on injection into the floor of […]
H157 Cell Line Product
[…] mutant p53, codon 306 exon 8, G to A; wild type K-, N- and Ha- ras. Cultured cells are keratin-positive. H157 cells are non-tumourigenic in athymic nude mice by subcutaneous […]
H357 Cell Line Product
[…] has mutant p53, codon 110 exon 4, G to A; the previously reported mutant Ha- ras status of this cell line: codon: 13, G to A, codon 61, A-G is […]
MCF10A pLA(empty) (negCTRL for hRas_V12 cell line) Product
This is a control line for the MCF10 H- Ras12 cell line from the same group at the VIB as it has the same pLA expression vector stably expressed but […]
