H376 Cell Line Product
[…] mutant p53, codon 266 exon 8, G to T; wild type K-, N-, and Ha- ras. H376 cells are non-tumourigenic in athymic nude mice by subcutaneous injection and on injection […]
H357 Cell Line Product
[…] has mutant p53, codon 110 exon 4, G to A; the previously reported mutant Ha- ras status of this cell line: codon: 13, G to A, codon 61, A-G is […]
PDVC57B Cell Line Product
[…] mutation in codon 231, (ATG-GTC) and an A-T tranversion at cod 61 of the H- ras gene. These events appear to be remarkably similar to the sequence of changes seen […]
Anti-GTP [3A5] Product
[…] which cycle between a GDP-bound inactive and a GTP-bound active conformation in a controlled manner. Ras GTPases are frequently mutated in cancer and so far only few experimental inhibitors exist. […]
Anti-Phospho-Raf1 (Ser338) [DPR/2/2A/3A] Product
[…] The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular […]
Anti-Rab11a [STo 7C10] Product
Rab11a is a member of the Rab family of Ras-like small GTPases, which regulate membrane trafficking events (e.g. vesicle recycling). Regulates endocytic recycling, may exert its functions by interacting with […]
2XSB Cell Line Product
Karyotyping, STR profiling, ICC, IHC, Live cell imaging, TMEM, SNP, whole exome sequencing, TERT promoter Sanger seq, Western blot, and Ras activation assays.
Anti-EGFR [EGFR1] Product
[…] (HER3) and c-erbB4 (HER4). EGFR activation signals multiple downstream signalling cascade pathways such as the Ras – ERK, PI3-K – Akt, Jak – STAT and PKC pathways which help in […]
Tumour Immunology – turning cancer’s weapons against itself Blog Post
[…] signalling pathways to evade immune attacks. Oncogenic mutations to key signalling pathways such as PI3K/mTOR, RAS/RAF/MAPK, Wnt/beta-catenin, STAT3 and NF-kB play dual roles in promoting tumour growth while also mediating […]
Tumour Immunology Antibodies Page
[…] tumour microenvironment and tumour immune escape. These signalling pathways include STAT3, β-Catenin, PI3K/PTEN/AKT/mTOR, p53, NF-κB, RAS/RAF/MAPK, and KRAS/MYC. They can drive effective immunocyte exclusion and disfunction, as well as recruitment […]
