RafTR Mouse Product
[…] nervous system (Neurofibromas). These tumours are initiated by Schwann cells in which the small GTPase Ras becomes basally more active. Raf is one of the key downstream effectors of Ras […]
Villin-Cre Apcfl/+ KRasG12D/+ Mouse Product
conditionally expressed an oncogenic K-rasD12 allele in the small intestine of adult mice either alone or in the context of Apc deficiency.
Malme-3M Cell Line Product
Malme-3M is a malignant human melanoma cell line that displays fibroblast-like morphology and grows in mixed culture (adherent-suspension). This cell line has been shown to be dependent upon micropthalmia-associated transcription […]
SK-MEL-2 Cell Line Product
SK-MEL-2 is one of a series of melanoma cell lines established from patient-derived tumour samples. This cell line expresses wildtype B-Raf and mutant N-Ras (Q61R).
SK-MEL-24 Cell Line Product
SK-MEL-24 is one of a series of melanoma cell lines established from patient-derived tumour samples. This cell line expresses wildtype B-Raf and wildtype N-Ras.
SK-MEL-1 Cell Line Product
[…] melanocytes established from patient-derived tumour samples. This cell line expresses mutant B-Raf (V600E) and wildtype N- Ras and were isolated from the skin of a 29-year-old, White male patient with melanoma.
MCF10A hRas_V12 cell line Product
[…] study signalling pathways in breast cancer. They can be grown in 3D culture. The addition of the H-Ras12 simulates breast cancer as 50% of breast cancers display increased H- Ras activity.
CT26 TTPKO cell line Product
[…] KRAS mutant colon carcinoma cell line. In some immunoresistant tumours, PD-L1 expression is upregulated by RAS activation. Via the MEK pathway, the MK2 kinase phosporylates and inhibits TTP, which negatively […]
EN-1078D Product
[…] for both estrogen receptor isoforms and progesterone receptor B, presents mutations in PTEN and K- Ras genes, one tumor suppressor and one oncogene frequently mutated in endometrial cancers. Cell line […]
SK-LU-1 Cell Line Product
[…] that displays epithelial morphology and grows in adherent culture. This cell line expresses mutant K- Ras (G12D) and has homozygous deletions in the CDH6 and CDKN2A genes. These cells do […]
