Cat. #162168
Zdbf2-KO mouse
Cat. #: 162168
Sub-type: Mouse
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Contributor
Institute: Institut Curie
Primary Citation: Juliane Glaser et. al. 2022 eLife. Jan 20:11:e65641. PMID: 35049495
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Tool name: Zdbf2-KO mouse
- Official nomenclature: C57BL6/Zdbf2embourc/Curie
- Research fields: Developmental biology
- Tool sub type: Mouse
- Crispr: Yes
- Description: The paternally expressed Zdbf2 gene controls neonatal growth in mice, in a dose-sensitive but parent-of-origin-independent manner. We further found that Zdbf2-KO neonates failed to fully activate hypothalamic circuits that stimulate appetite, and suffered milk deprivation and diminished circulating Insulin Growth Factor 1 (IGF-1).
- Genetic background: CRISPR-Cas9 was injected into C57BL6/J zygotes. The line was established after at least two backcrosses to C57BL6/J.
- Phenotype: Growth retardation from birth with increased lethality. Phenotype is observed in homozygotes and in animals with paternal mutation only.
- Zygosity: Heterozygous
- Strain: C57BL6/J
- Production details: Exon6 was removed using 2 flanking sgRNAs.
- Recommended controls: WT littermates
Handling
- Shipping conditions: Spermatoza- Dry Ice
References
- Juliane Glaser et. al. 2022 eLife. Jan 20:11:e65641. PMID: 35049495
