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#162168

Zdbf2-KO mouse

Cat. #162168

Zdbf2-KO mouse

Cat. #: 162168

Sub-type: Mouse

Availability: 3-4 weeks

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Institute: Institut Curie

Primary Citation: Juliane Glaser et. al. 2022 eLife. Jan 20:11:e65641. PMID: 35049495

Tool Details
Handling
References

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

  • Tool name: Zdbf2-KO mouse
  • Official nomenclature: C57BL6/Zdbf2embourc/Curie
  • Research fields: Developmental biology
  • Tool sub type: Mouse
  • Crispr: Yes
  • Description: The paternally expressed Zdbf2 gene controls neonatal growth in mice, in a dose-sensitive but parent-of-origin-independent manner. We further found that Zdbf2-KO neonates failed to fully activate hypothalamic circuits that stimulate appetite, and suffered milk deprivation and diminished circulating Insulin Growth Factor 1 (IGF-1).
  • Genetic background: CRISPR-Cas9 was injected into C57BL6/J zygotes. The line was established after at least two backcrosses to C57BL6/J.
  • Phenotype: Growth retardation from birth with increased lethality. Phenotype is observed in homozygotes and in animals with paternal mutation only.
  • Zygosity: Heterozygous
  • Strain: C57BL6/J
  • Production details: Exon6 was removed using 2 flanking sgRNAs.
  • Recommended controls: WT littermates

Handling

  • Shipping conditions: Spermatoza- Dry Ice

References

  • Juliane Glaser et. al. 2022 eLife. Jan 20:11:e65641. PMID: 35049495

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