Zdbf2-KO mouse

Zdbf2-KO mouse: The paternally expressed Zdbf2 gene controls neonatal growth in mice, in a dose-sensitive but parent-of-origin-independent manner. We further found that Zdbf2-KO neonates failed to fully activate hypothalamic circuits that stimulate appetite, and suffered milk deprivation and diminished circulating Insulin Growth Factor 1 (IGF-1).

Contributors

Institute
Institut Curie
Cat. #: 162168
Research Fields: Developmental biology
Zygosity: Heterozygous
Strain: C57BL6/J
Phenotype: Growth retardation from birth with increased lethality. Phenotype is observed in homozygotes and in animals with paternal mutation only.
Primary citation: Juliane Glaser et. al. 2022 eLife. Jan 20:11:e65641. PMID: 35049495
Official nomenclature: C57BL6/Zdbf2embourc/Curie
Product description: The paternally expressed Zdbf2 gene controls neonatal growth in mice, in a dose-sensitive but parent-of-origin-independent manner. We further found that Zdbf2-KO neonates failed to fully activate hypothalamic circuits that stimulate appetite, and suffered milk deprivation and diminished circulating Insulin Growth Factor 1 (IGF-1).
CRISPR: Yes
Genetic background: CRISPR-Cas9 was injected into C57BL6/J zygotes. The line was established after at least two backcrosses to C57BL6/J.
Production details: Exon6 was removed using 2 flanking sgRNAs.
Shipping conditions: Spermatoza- Dry Ice
References:

Juliane Glaser et. al. 2022 eLife. Jan 20:11:e65641. PMID: 35049495

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