TsixTAD-KO mouse

TsixTAD-KO mouse: This line was generated in the context of studying the relationship between chromosome organisation and gene expression at the X-inactivation centre, the regulatory locus that triggers X-chromosome inactivation. It could also be used to investigate the functions of the genes that are lost within the ~245kb deletion, including the poorly characterised genes Nap1L2, […]

Contributors

Inventor Institute
Edith HEARD; Rafael GALUPA; Fatima EL MARJOU; Colin JOUHANNEAU Institut Curie
Cat. #: 162172
Research Fields: Genetics
Zygosity: Homozygous
Strain: B6D2F1
Primary citation: Rafael Galupa et.al. 2020. Mol Cell. Jan 16;77(2):352-367.e8. PMID: 31759823.
Official nomenclature: B6D2Fn-Tsix-TADem2Heard/Curie
Product description: This line was generated in the context of studying the relationship between chromosome organisation and gene expression at the X-inactivation centre, the regulatory locus that triggers X-chromosome inactivation. It could also be used to investigate the functions of the genes that are lost within the ~245kb deletion, including the poorly characterised genes Nap1L2, Cdx4, Chic1 and Tsx, among others.
CRISPR: Yes
Shipping conditions: Sperm / dry ice
References:

Rafael Galupa et.al. 2020. Mol Cell. Jan 16

77(2):352-367.e8. PMID: 31759823.

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