#151578

Trex1 -/- Mouse

Cat. #151578

Trex1 -/- Mouse

Cat. #: 151578

Sub-type: Mouse

Availability: 6-8 weeks

Disease: Antiviral-like autoimmunity

Model: Knock-Out

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Contributor

Inventor: Tomas Lindahl

Institute: Cancer Research UK, London Research Institute: Clare Hall Laboratories

Tool Details
Handling
Target Details
Related Tools
References

Tool Details

*FOR RESEARCH USE ONLY

  • Tool name: Trex1 -/- Mouse
  • Research fields: Drug development;Genetics;Immunology
  • Tool sub type: Mouse
  • Disease: Antiviral-like autoimmunity
  • Model: Knock-Out
  • Conditional: No
  • Description: Model for the human recessive autoimmune disease Aicardi-Goutieres syndrome; potential use for testing of therapeutic agents; identifies a novel immune pathway. Trex1 KO mouse
  • Genetic background: Standard gene-targeting in ES cells using a genomic DNA construct flanking the Trex1 locus in which amino acids 103 to 207 of the Trex1 ORF were replaced by a neomycin resistance gene/polyA signal.
  • Phenotype: Autoimmunity manifested as inflammatory myocarditis / reduced lifespan
  • Zygosity: Homozygous
  • Production details: Standard gene-targeting in ES cells using a genomic DNA construct flanking the Trex1 locus in which amino acids 103 to 207 of the Trex1 ORF were replaced by a neomycin resistance gene/polyA signal.

Handling

  • Shipping conditions: Embryo/Spermatoza- Dry Ice

Target Details

  • Target: TREX1

Related Tools

  • Related tools: MEF Trex1 KO Cell Line

References

  • Yang et al. 2007. Cell. 131(5):873-86. PMID: 18045533.
  • Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease.
  • Morita et al. 2004. Mol Cell Biol. 24(15):6719-27. PMID: 15254239.
  • Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA exonuclease develop inflammatory myocarditis.