#152784

Mapt-9E18 phosphomimetic Tau Mouse

Cat. #152784

Mapt-9E18 phosphomimetic Tau Mouse

Cat. #: 152784

Sub-type: Mouse

Availability: 6-8 weeks

Disease: Alzheimer's disease

Model: Knock-In

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Contributor

Inventor: Michael Coleman

Institute: Babraham Institute

Tool Details
Target Details
Related Tools
References

Tool Details

*FOR RESEARCH USE ONLY

  • Tool name: Mapt-9E18 phosphomimetic Tau Mouse
  • Alternate name: MAPT, Neurofibrillary tangle protein, paired helical filament-tau, PHF-tau
  • Research fields: Cell biology;Genetics;Neurobiology
  • Tool sub type: Mouse
  • Disease: Alzheimer's disease
  • Model: Knock-In
  • Conditional: No
  • Description: Hyperphosphorylation and fibrillar aggregation of the microtubule-associated protein tau (MAPT) are key features of Alzheimer's disease and other tauopathies. Tauopathies are characterized by aggregation of microtubule-associated protein tau into neurofibrillary tangles (NFTs). The Mapt-9E18 phosphomimetic tau knockin mouse expresses phosphomimetic tau with 18 glutamate substitutions at serine and/or threonine residues in the proline-rich and first microtubule-binding domains to model hyperphosphorylation. This is a model of frontotemporal dementia with parkinsonism linked to tau mutations on chromosome 17 (FTDP-17T). There is a complementary phosphodefective counterpart mouse that has matched alanine substitutions (Mapt-9A18).
  • Strain: C57BL/6

Target Details

  • Target: Microtubule-associated protein Tau

Related Tools

  • Related tools: Mapt-9A18 phosphodefective Tau Mouse

References

  • Gilley J et al. Neurobiol Aging. 2016 Mar
  • 39:1-18
  • PMID: 26923397