#151551

Inva2b1 Mouse

Cat. #151551

Inva2b1 Mouse

Cat. #: 151551

Sub-type: Mouse

Availability: 6-8 weeks

Disease: Psoriasis

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Fiona Watt

Institute: Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details
Handling
Target Details
References

Tool Details

*FOR RESEARCH USE ONLY

  • Tool name: Inva2b1 Mouse
  • Research fields: Cell biology;Genetics
  • Tool sub type: Mouse
  • Disease: Psoriasis
  • Conditional: Yes
  • Conditional description: Conditional expression of integrins under involucrin promoter giving tissue-specific suprabasal epidermal expression.
  • Description: Disease model for psoriasis; in vivo study of human alpha2 and beta1 integrin transgene expression in skin.
  • Genetic background: Involucrin - integrin transgene expression constructs were injected into fertilized oocytes from F1 hybrid CBAxC57Bl/6 mice. Transgene-positive mice were back-crossed to generate individual founder lines. alpha2 founder line was crossed with beta1 founder line to generate alpha2beta1 line.
  • Phenotype: Skin abnormalities (abnormal keratinocyte differentiation, hyperproliferation, inflammatory lesions)
  • Zygosity: Heterozygous
  • Production details: Involucrin - integrin transgene expression constructs were injected into fertilized oocytes from F1 hybrid CBAxC57Bl/6 mice. Transgene-positive mice were back-crossed to generate individual founder lines. alpha2 founder line was crossed with beta1 founder line to generate alpha2beta1 line.
  • Additional notes: Mice present phenotype very similar to human psoriasis disease.

Handling

  • Shipping conditions: Embryo/Spermatoza- Dry Ice

Target Details

  • Target: Alpha2 intergrin, beta1 integrin

References

  • Carroll et al. 1995. Cell. 83(6):957-68. PMID: 8521519.
  • Suprabasal integrin expression in the epidermis of transgenic mice results in developmental defects and a phenotype resembling psoriasis.