Inva2b1 Mouse

Disease model for psoriasis; in vivo study of human alpha2 and beta1 integrin transgene expression in skin.

Contributors

Inventor Institute
Fiona Watt Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Cat. #: 151551
Research Fields: Cell biology;Genetics
Target: Alpha2 intergrin, beta1 integrin
disease: Psoriasis
Zygosity: Heterozygous
Phenotype: Skin abnormalities (abnormal keratinocyte differentiation, hyperproliferation, inflammatory lesions)
Product description: Disease model for psoriasis; in vivo study of human alpha2 and beta1 integrin transgene expression in skin.
Conditional: Yes
Conditional description: Conditional expression of integrins under involucrin promoter giving tissue-specific suprabasal epidermal expression.
Genetic background: Involucrin – integrin transgene expression constructs were injected into fertilized oocytes from F1 hybrid CBAxC57Bl/6 mice. Transgene-positive mice were back-crossed to generate individual founder lines. alpha2 founder line was crossed with beta1 founder line to generate alpha2beta1 line.
Production details: Involucrin – integrin transgene expression constructs were injected into fertilized oocytes from F1 hybrid CBAxC57Bl/6 mice. Transgene-positive mice were back-crossed to generate individual founder lines. alpha2 founder line was crossed with beta1 founder line to generate alpha2beta1 line.
Additional notes: Mice present phenotype very similar to human psoriasis disease.
Shipping conditions: Embryo/Spermatoza- Dry Ice
References:

Carroll et al. 1995. Cell. 83(6):957-68. PMID: 8521519.

Suprabasal integrin expression in the epidermis of transgenic mice results in developmental defects and a phenotype resembling psoriasis.

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