Cat. #156432
Homozygous Mutant DISC1 (1001) mouse
Cat. #: 156432
Sub-type: Mouse
Availability: 6-8 weeks
Disease: Schizophrenia and psychiatric illnesses
Model: Mutant
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Mikhail Plentnikov
Institute: Johns Hopkins University
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Tool name: Homozygous Mutant DISC1 (1001) mouse
- Research fields: Drug development;Neurobiology
- Tool sub type: Mouse
- Disease: Schizophrenia and psychiatric illnesses
- Model: Mutant
- Description: This homozygous mouse strain (1001) carries mutant hDISC1 without gross developmental defects. In this strain, the expression of mutant hDISC1 is restricted to forebrain regions using TET-off system under the control of CAMKII. In addition, the expression can be suppressed by feeding the mice with doxycycline (DOX). These transgenic animals allow selective control of mutant hDISC1 expression in forebrain neurons and, herein provide a valuable research tool to study pathogenesis of schizophrenia and to conduct experimental therapeutics for the disease. This line is on a mixed background (B6; SJL; CBA).
- Genetic background: B6; SJL; CBA
- Zygosity: Homozygous
Target Details
- Target: DISC1
References
- Pogorelov et al. 2012. Neuropharmacology. 62(3):1242-51. PMID: 21315744.
- Abazyan et al. 2010. Biol Psychiatry. 68(12):1172-81. PMID: 21130225.
