G0S2-flox mouse

Cat. #160867

G0S2-flox mouse

Cat. #: 160867

Sub-type: Mouse

Availability: 6-8 weeks

Model: Knock-Out

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Inventor: Franz Radner

Institute: University of Graz

Tool Details
Target Details

Tool Details


  • Tool name: G0S2-flox mouse
  • Alternate name: G0/G1 swithc gene 2
  • Research fields: Apoptosis and autophagy;Cancer;Cell biology;Metabolism
  • Tool sub type: Mouse
  • Model: Knock-Out
  • Conditional: Yes
  • Conditional description: Flox flanked gene ready for deletion
  • Description: seful model for the generation of tissue/cell specific G0S2-deficient mice. Animals might be useful for studies, e.g.on energy metabolism or oncology.
  • Genetic background: These mice were generated using HM1-ES cells. ES cell clones were injected into C57BL/6J blastocysts to enable coat colour selection of the chimeras. Mice were subsequently backcrossed to C57BL/6J (≥ 10 generations). When kept as a homozygous colony, mice are backcrossed regularly to C57BL/6J to avoid generation of subpopulations.
  • Phenotype: These mice are conditional ready, and phenotypical identical to C57BL/6J mice.
  • Zygosity: Homozygous
  • Strain: C57BL/6J
  • Production details: The whole G0s2 gene sequence was targeted and flanked by loxP sites. Further details are available upon request.
  • Breeding information: Good breeder. Homozygous mice may be bred together to maintain a live colony.

Target Details

  • Target: G0/G1 switch gene 2


  • Heier et al. 2015. J Biol Chem. 290(43):26141-50. PMID: 26350455.