G0S2-flox mouse

Useful model for the generation of tissue/cell specific G0S2-deficient mice. Animals might be useful for studies, e.g.on energy metabolism or oncology.

Contributors

Inventor Institute
Franz Radner University of Graz
Cat. #: 160867
Research Fields: Apoptosis and autophagy;Cancer;Cell biology;Metabolism
Target: G0/G1 switch gene 2
Model: Knock-Out
Zygosity: Homozygous
Strain: C57BL/6J
Phenotype: These mice are conditional ready, and phenotypical identical to C57BL/6J mice.
Alternate name: G0/G1 swithc gene 2
Product description: seful model for the generation of tissue/cell specific G0S2-deficient mice. Animals might be useful for studies, e.g.on energy metabolism or oncology.
Conditional: Yes
Conditional description: Flox flanked gene ready for deletion
Genetic background: These mice were generated using HM1-ES cells. ES cell clones were injected into C57BL/6J blastocysts to enable coat colour selection of the chimeras. Mice were subsequently backcrossed to C57BL/6J (≥ 10 generations). When kept as a homozygous colony, mice are backcrossed regularly to C57BL/6J to avoid generation of subpopulations.
Production details: The whole G0s2 gene sequence was targeted and flanked by loxP sites. Further details are available upon request.
References:

Heier et al. 2015. J Biol Chem. 290(43):26141-50. PMID: 26350455.

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