G0S2-flox mouse

Useful model for the generation of tissue/cell specific G0S2-deficient mice. Animals might be useful for studies, e.g.on energy metabolism or oncology.

Contributors

Inventor Institute
Franz Radner University of Graz
Cat. #: 160867
Research Fields: Apoptosis and autophagy;Cancer;Cell biology;Metabolism
Target: G0/G1 switch gene 2
Model: Knock-Out
Zygosity: Homozygous
Strain: C57BL/6J
Phenotype: These mice are conditional ready, and phenotypical identical to C57BL/6J mice.
Alternate name: G0/G1 swithc gene 2
Product description: seful model for the generation of tissue/cell specific G0S2-deficient mice. Animals might be useful for studies, e.g.on energy metabolism or oncology.
Conditional: Yes
Conditional description: Flox flanked gene ready for deletion
Genetic background: These mice were generated using HM1-ES cells. ES cell clones were injected into C57BL/6J blastocysts to enable coat colour selection of the chimeras. Mice were subsequently backcrossed to C57BL/6J (≥ 10 generations). When kept as a homozygous colony, mice are backcrossed regularly to C57BL/6J to avoid generation of subpopulations.
Production details: The whole G0s2 gene sequence was targeted and flanked by loxP sites. Further details are available upon request.
References:

Heier et al. 2015. J Biol Chem. 290(43):26141-50. PMID: 26350455.

Related Tools for Mouse models

Cat. # Tool Name
151467 p23+/- Mouse Key Info View Tool
151482 Jagged1 Floxed Mouse Key Info View Tool
151502 CyclinD1-/- KO Mouse Key Info View Tool
151481 DLL1 Floxed Mouse Key Info View Tool
151554 SAP1 Mouse Key Info View Tool

Tool enquiry

Please ensure you use your organisation email address rather than personal where possible, as this helps us locate your organisation in our system faster.

Please note we may take up to three days to respond to your enquiry.

CancerTools.org uses the contact information provided to respond to you about our research tools and service. For more information please review our privacy policy.