Fibroblast specific Spag17 knockout mouse

fibroblast specific, Tamoxifen inducible knockout mouse model for the deletion of the Spag17 gene

Contributors

Inventor Institute
Maria E Teves Ph.D., Jerome F Strauss III M.D Ph.D., and John Varga M.D. Virginia Commonwealth University
Cat. #: 161683
Research Fields: Systemic sclerosis and fibrosis
disease: Fibrocystic disease; Systemic sclerosis
Model: Knock-out
Phenotype: Multi-organ fibrosis
Primary citation: Sapao et al. J Invest Dermatol. 143(2):284-293 PMID: 36116512
Product description: This is a fibroblast specific, Tamoxifen inducible knockout mouse model for the deletion of the Spag17 gene. Reserachers identified the Spag17 gene as one differentially regulated in fibrotic diseases and created a mouse model was created with inducible fibroblast specific Spag17 knockout. Knockout Spag17 mice show significant fibrosis in skin, heart, lungs, kidneys, and skeletal muscle between 4-6 months of age. These mice have greater collagen deposition, enhanced fibroblast to myofibro…
CRISPR: No
References:

Sapao et al. J Invest Dermatol. 143(2):284-293 PMID: 36116512

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