Cat. #161683
Fibroblast specific Spag17 knockout mouse
Cat. #: 161683
Disease: Fibrocystic disease; Systemic sclerosis
Model: Knock-out
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Contributor
Inventor: Maria E Teves Ph.D., Jerome F Strauss III M.D Ph.D., and John Varga M.D.
Institute: Virginia Commonwealth University
Primary Citation: Sapao et al. J Invest Dermatol. 143(2):284-293 PMID: 36116512
Tool Details
*FOR RESEARCH USE ONLY
- Tool name: Fibroblast specific Spag17 knockout mouse
- Disease: Fibrocystic disease; Systemic sclerosis
- Model: Knock-out
- Crispr: No
- Description: This is a fibroblast specific, Tamoxifen inducible knockout mouse model for the deletion of the Spag17 gene.
Reserachers identified the Spag17 gene as one differentially regulated in fibrotic diseases and created a mouse model was created with inducible fibroblast specific Spag17 knockout. Knockout Spag17 mice show significant fibrosis in skin, heart, lungs, kidneys, and skeletal muscle between 4-6 months of age. These mice have greater collagen deposition, enhanced fibroblast to myofibro... - Phenotype: Multi-organ fibrosis
References
- Sapao et al. J Invest Dermatol. 143(2):284-293 PMID: 36116512
