#161768

TOV-1369TR cell line

Cat. #161768

TOV-1369TR cell line

Cat. #: 161768

Organism: Human

Tissue: Derived from solid tumor of patient diagnosed with high-grade serous ovarian cancer at specific time points at diagnosis and relapse

£575.00

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Contributor

Inventor: Anne-Marie Mes-Masson and Diane Provencher

Institute: Centre Hospitalier de L’université de Montréal

Primary Citation: Létourneau et al. 2012. BMC Cancer. (12): 379. PMID: 22931248

Tool Details
Handling
References

Tool Details

*FOR RESEARCH USE ONLY

  • Name: TOV-1369TR cell line
  • Alternate name: TOV-1369TR
  • Organism: Human
  • Gender: Female
  • Tissue: Derived from solid tumor of patient diagnosed with high-grade serous ovarian cancer at specific time points at diagnosis and relapse
  • Donor: Grade 3 – Stage IIIC; Mutations: TP53 Exon 7; Post-treatment for breast cancer 2 years before
  • Morphology: Expresssion of tumor suppressor p53 present. Strong HER2 expression detected in protein extracts and observed in solid tissues by IHC. Spheroid formation: no
  • Growth properties: Adherent
  • Crispr: No
  • Receptors of note: No
  • Description: Epithelial ovarian cancer cell lines spontaneously derived from solid tumor at specific time points at diagnosis and relapse. Post-treatment for breast cancer 2 years before
  • Production details: Established using the Scrape method where tumor tissue was scraped into a 100mm plate with complete OSE medium and maintained for 40 days with medium replaced weekly.
  • Additional notes: Patient was diagnosed with breast cancer 18 months before ovarian cancer diagnosis. After surgical resection for breast cancer and 14 months before ovarian cancer diagnosis, patient had docetaxel treatment. Patient was also entrolled in a clinical trial obtaining doxorubicin, docetaxel with or without cyclophosphamide and received radiotherapy 12 months before ovarian cancer diagnosis. After ovarian cancer diagnosis, patient received paclitaxel and carboplatin for 5 months and was initially r...

Handling

  • Growth medium: OSE medium contains 10% FBS, 0.5ug/mL amphotericin B and 50 ug/mL gentamicin
  • Atmosphere: Hypoxic condition of 5%O2 and 5%CO2
  • Cultured in antibiotics: Amphotericin B and Gentamicin

References

  • Tomas et al. 2023. J Ovarian Res. 11
  • 16(1):70. PMID: 37038202 Vias et al. 2023. Elife. 11
  • 12:e83867. PMID: 37166279 Jubelin et al. 2022. Cell Biosci. 11
  • 12(1):155. PMID: 36089610 Canals et al. 2022. Front Oncol. 4
  • 12:856424. PMID: 35600398