Sdhb fl/fl Cell Line

Succinate dehydrogenase (SDH) is an enzyme complex found in the inner mitochondrial membrane of mammalian mitochondria and many bacterial cells.

Contributors

Inventor Institute
Eyal Gottlieb Cancer Research UK, Glasgow: The Beatson Institute
Cat. #: 153294
Unit size: 1×10^6 cells / vial
Research Fields: Cancer;Drug development;Metabolism
Organism: Mouse
Tissue: Kidney
Model: Conditional KO
Alternate name: Succinate dehydrogenase, SDH, Succinate-coenzyme Q reductase, SQR
Product description: Succinate dehydrogenase (SDH) is an enzyme complex found in the inner mitochondrial membrane of mammalian mitochondria and many bacterial cells. SDH is the only enzyme that participates in both the electron transport chain and citric acid cycle. The enzymatic function of SDH oxidises succinate to fumarate in the tricarboxylic acid cycle and loosing this function is associated with cancer formation.
Conditional: Yes
Conditional description: Deletion of succinate dehydrogenase can be achieved by intracellular expression of Cre recombinase
Cellosaurus ID: CVCL_HG11
disease: Cancer
Format: Frozen
Storage conditions: Liquid Nitrogen
Shipping conditions: Dry ice
Mycoplasma free: Yes
Biosafety level: 1
References:

Cardaci et al. 2015. Nat Cell Biol. 17(10):1317-26. PMID: 26302408.

Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis.

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