Cat. #153294
Sdhb fl/fl Cell Line
Cat. #: 153294
Unit size: 1x10^6 cells / vial
Availability: 8-10 weeks
Organism: Mouse
Tissue: Kidney
Disease: Cancer
Model: Conditional KO
£575.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Eyal Gottlieb
Institute: Cancer Research UK, Glasgow: The Beatson Institute
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Sdhb fl/fl Cell Line
- Alternate name: Succinate dehydrogenase, SDH, Succinate-coenzyme Q reductase, SQR
- Research fields: Cancer;Drug development;Metabolism
- Organism: Mouse
- Tissue: Kidney
- Disease: Cancer
- Model: Conditional KO
- Conditional: Yes
- Conditional description: Deletion of succinate dehydrogenase can be achieved by intracellular expression of Cre recombinase
- Description: Succinate dehydrogenase (SDH) is an enzyme complex found in the inner mitochondrial membrane of mammalian mitochondria and many bacterial cells. SDH is the only enzyme that participates in both the electron transport chain and citric acid cycle. The enzymatic function of SDH oxidises succinate to fumarate in the tricarboxylic acid cycle and loosing this function is associated with cancer formation.
- Biosafety level: 1
- Cellosaurus id: CVCL_HG11
Target Details
- Target: Succinate dehydrogenase
Handling
- Format: Frozen
- Unit size: 1x10^6 cells / vial
- Shipping conditions: Dry ice
- Storage conditions: Liquid Nitrogen
- Mycoplasma free: Yes
Related Tools
- Related tools: Sdhb -/- CL 5 Cell Line ; Sdhb -/- CL 7 Cell Line ; SDHB Floxed Mouse
References
- Cardaci et al. 2015. Nat Cell Biol. 17(10):1317-26. PMID: 26302408.
- Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis.
