PEA1 Cell Line

A patient-derived ovarian adenocarcinoma cell line used as a chemosensitive comparator for studies of chemotherapy response, drug response and ovarian cancer biology. Exclusive to CancerTools. Save 30% on this cell line this summer. Use code SUM26CELL at checkout.

Contributors

Inventor Institute
Simon Langdon Cancer Research UK Edinburgh Centre
SKU: 151678
Product description: PEA1 is a patient-derived human ovarian adenocarcinoma cell line established from a malignant pleural effusion. It forms a patient-matched pair with PEA2, which was derived from the same patient after acquisition of resistance to platinum-based chemotherapy. PEA1 is the more chemosensitive comparator in this pair, supporting studies of chemotherapy response, platinum sensitivity, drug response and treatment-associated change in ovarian cancer models.
Additional notes: PEA1 is one of nine cell lines from the PE ovarian adenocarcinoma panel, which was derived from four patients at different stages of ovarian cancer, from various malignant sites and at various treatment stages. The wider panel has been used as a model system for research into mechanisms of oestrogen action in ovarian adenocarcinoma tumour cells and for studies of oestrogen agonist/antagonist efficacy and toxicity. PEA1 was collected prior to cisplatin and prednimustine treatment and has been reported to show poor growth in semi-solid medium, including agar.
Cellosaurus ID: CVCL_2682
Cat. #: 151678
Cancer types: Ovarian cancer
Research Fields: Cancer;Drug development
Organism: Human
Tissue: Ovary
Model: Tumour line
Growth properties: Adherent
Cancer Types In Detail: Adenocarcinoma
Format: Frozen
Shipping conditions: Dry ice
Growth medium: RPMI 1640 + 2mM Glutamine + 2mM Sodium Pyruvate + 10% Foetal Bovine Serum (FBS).
Subculture routine: Split sub-confluent cultures (70-80%) 1:4 to 1:10 seeding at 2- 3 x 10^4 cells/cm²
References:

Matassa et al. 2016. Cell Death Differ. :. PMID: 27206315.

Beaufort et al. 2014. PLoS One. 9(9):e103988. PMID: 25230021.

Langdon et al. 1990. Br J Cancer. 62(2):213-6. PMID: 2386737.

Langdon et al. 1988. Cancer Res. 48(21):6166-72. PMID: 3167863.

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PEA1 Cell Line.Image courtesy of the European Collection of Authenticated Cell Cultures (ECACC)

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