PEA1 Cell Line

PEA1 is an adherent cell line derived from a malignant effusion from the pleural cavity of a patient with a poorly differentiated adenocarcinoma.

Contributors

Inventor Institute
Simon Langdon Cancer Research UK Edinburgh Centre
Cat. #: 151678
Tool sub type: 10XUAS IVS p10
Cancer types: Adenocarcinoma;Adenocarcinoma
Organism: Human
Tissue: Ovary
Gender: Male
Model: Tumour line
Growth properties: Adherent
Cancer Types In Detail: Adenocarcinoma;Adenocarcinoma
Product description: The PEA1 cell line is one of nine from the PE ovarian adenocarcinoma panel (derived from 4 patients at varying stages of ovarian cancer, isolated from various malignant sites, and at various treatment stages) which provides a model system for research into the mechanism of oestrogen action on ovarian adenocarcinoma tumour cells, and for the study of efficacy and toxicity of oestrogen protagonists. It is an adherent cell line derived from a malignant effusion from the pleural cavity of a patient with a poorly differentiated adenocarcinoma. This cell line was collected prior to treatment with cisplatin and prednimustine. PEA1 exhibits poor growth in semi-solid medium (agar) and is from the same patient as the PEA2 cell line.
Gender: Male
CRISPR: Yes
Conditional: Yes
Cellosaurus ID: CVCL_2682
Format: Frozen
Shipping conditions: Dry ice
Growth medium: RPMI 1640 + 2mM Glutamine + 2mM Sodium Pyruvate + 10% Foetal Bovine Serum (FBS).
Subculture routine: Split sub-confluent cultures (70-80%) 1:4 to 1:10 seeding at 2- 3 x 10^4 cells/cm²
Mycoplasma free: Yes
References:

Matassa et al. 2016. Cell Death Differ. :. PMID: 27206315.

Beaufort et al. 2014. PLoS One. 9(9):e103988. PMID: 25230021.

Langdon et al. 1990. Br J Cancer. 62(2):213-6. PMID: 2386737.

Langdon et al. 1988. Cancer Res. 48(21):6166-72. PMID: 3167863.

Citations And Reviews

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