OvsahoCarbo Cell Line

Platinum-resistant HGSC cancer cells.

Contributors

Inventor Institute
Michelle Lockley Queen Mary University of London, UK.
SKU: 161759
Product description: Platinum-resistant HGSC cancer cells with a growth advantage in the presence of therapy that expand to create drug-resistant tumours.
Gender: Female
CRISPR: No
Production details: Cells were cultured in vitro in increasing concentrations of either cisplatin or carboplatin until an increase in IC50 between two and ten-fold was achieved to reflect the resistance observed in human patients
Parental cell line: Ovsaho cell line
Model description: Platinum-resistant HGSC in vivo cell line
Cat. #: 161759
Cancer types: Ovarian cancer
Research Fields: Cancer
Organism: Human
Tissue: Ovary
Gender: Female
Model: Mutant
Growth properties: Adherent
Primary citation: J I Hoare et al. 2022. Gynecol Oncol. 167(1):96-106. PMID: 35918200
Growth medium: RPMI containing 10% FBS and 1% penicillin/streptomycin. Cells should be cultured without drug but used at low passage to ensure drug resistance is maintained.
Temperature: 37° C
Mycoplasma free: Yes
References:

J I Hoare et al. 2022. Gynecol Oncol. 167(1):96-106. PMID: 35918200.

Images

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Platinum-resistance can be induced in HGSC cell lines and is maintained after drug withdrawal.

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