Cat. #162023

Melan-mu3 cell line

Name: Melan-mu3 cell line
SKU: 162023
Availability: InStock

Cat. #: 162023

Availability: 8-10 weeks

Organism: Mouse

Tissue: Skin

Disease: Hermansky-Pudlak syndrome

Model: Immortalised non-cancerous cell lines

£575.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

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Contributor

Inventor: Elena Sviderskaya

Institute: St. George's University London

Tool Details

Applications

Handling

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

Name: Melan-mu3 cell line
Organism: Mouse
Tissue: Skin
Disease: Hermansky-Pudlak syndrome
Morphology: Small, oval-fusiform
Model: Immortalised non-cancerous cell lines
Description: The melan-mu1, -mu2 and mu-3 cell lines are immortal melanocyte cell lines derived from neonatal muted (Mutedmu/mu) Ink4aArf -/-B6.CHMU/Le mice. These cell lines lack muted, a subunit of the biogenesis of lysosome-related organelles complex 1 (BLOC-1). BLOC-1 is involved in cargo sorting from early-endosomes towards lysosome related organelles, including melanosomes. Pathogenic variants in the human ortholog of muted cause a form of Hermansky-Pudlak syndrome (HPS), HPS-11. HPS is a group of disorders characterised by hypopigmentation, bleeding tendency and other variable symptoms. These cells are hypopigmented despite the expression of tyrosinase. These cells are a useful model for HPS and for the study of trafficking of cargoes towards lysosome-related organelles
Application: Melanocyte cell biology

Applications

Application: Melanocyte cell biology

Handling

Growth medium: RPMI + FBS (10%) + TPA (200 nM) + cholera toxin (CT) (200 pM)
Storage conditions: liquid N2