Melan-In4 cell line

Immortal melanocyte cell lines derived from the skin of neonatal Mlphln/Mlphln null Ink4aArf -/- C57BL6/J mice

Contributors

Inventor Institute
Elena Sviderskaya St. George's University London
Cat. #: 162017
Organism: Mouse
Tissue: Skin
Model: Immortalised non-cancerous cell lines
Morphology: Small, oval-fusiform
Product description: The melan-ln1, -ln2, ln-3 and ln-4 lines are immortal melanocyte cell lines derived from the skin of neonatal Mlphln/Mlphln null Ink4aArf -/- C57BL6/J mice. The leaden gene product (melanophilin, Mlph) is a Rab27a effector protein involved in melanosome transport and as such, these leaden null melanocytes display perinuclear clustering of pigmented melanosomes. These murine melanocytes are a model of the human disorder Griscelli syndrome in which patients present with hypopigmented skin and hair and immunodeficiencies. These melanocytes are a useful tool for studies of pigmentation genetics and transport of photoprotective eumelanin.
Storage conditions: liquid N2
Growth medium: RPMI + FBS (10%) + TPA (200 nM) + cholera toxin (CT) (200 pM)

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