E3 Cell Line

The E3 cell line was developed to examine the possibility of using the MUC1 gene and its products in active immunization against breast and other carcinomas.

Contributors

Inventor Institute
Joyce Taylor-Papadimitriou ; Joy Burchell Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Cat. #: 152597
Tool sub type: Continuous
Unit size: 1×10^6 cells / vial
Cancer types: Gynaecologic cancer
Research Fields: Cancer;Drug development;Immunology
Organism: Mouse
Tissue: Breast
Model: Immortalised Line
Cancer Types In Detail: Mammary
Product description: The E3 cell line was developed to examine the possibility of using the MUC1 gene and its products in active immunization against breast and other carcinomas. The human MUC1 gene codes for a type I membrane glycoprotein that is normally expressed on the apical surface of most glandular epithelial cells, but which is upregulated and under- or differently glycosylated in carcinomas; these differences in glycosylation lead to the exposure of novel epitopes which are not found on the normally processed mucin and can therefore be used as targets.
Production details: The E3 cell line was developed from the 410.4 murine mammary cell line by transfection of the hygromycin resistance gene with the MUC1 gene.
Cellosaurus ID: CVCL_W345
Parental cell line: 410.4
disease: Cancer
Format: Frozen
Shipping conditions: Dry ice
Growth medium: DMEM, 10S , 400?„?žg/ml hygromycin
References:

Julien et al. 2009. Br J Cancer. 100(11):1746-54. PMID: 19436292.

Sialyl-Tn vaccine induces antibody-mediated tumour protection in a relevant murine model.

Smith et al. 1999. Immunology. 97(4):648-55. PMID: 10457219.

Expression of B7.1 in a MUC1-expressing mouse mammary epithelial tumour cell line inhibits tumorigenicity but does not induce autoimmunity in MUC1 transgenic mice.

Lalani et al. 1991. J Biol Chem. 266(23):15420-6. PMID: 1714457.

Expression of the gene coding for a human…

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