#153986

Anti-SUMO-2/SUMO-3 (8A2)

Cat. #153986

Anti-SUMO-2/SUMO-3 (8A2)

Cat. #: 153986

Sub-type: Primary antibody

Unit size: 100 ug

Target: SUMO-2 and SUMO-3 but does not recognize SUMO-1

Class: Monoclonal

Application: ChIP ; IHC ; IF ; IP ; WB

Reactivity: Human

Host: Mouse

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Michael Matunis

Institute: Johns Hopkins University

Tool Details
Target Details
Applications
Handling
References

Tool Details

*FOR RESEARCH USE ONLY

  • Name: Anti-SUMO-2/SUMO-3 (8A2)
  • Alternate name: Small ubiquitin-related modifier 2; HSMT3; SMT3 homolog 2; SUMO-3; Zentrin-2; Ubiquitin-like protein SMT3B; Smt3B
  • Research fields: Apoptosis and autophagy;Biochemistry;Cell biology;Cell signaling and signal transduction;Genetics
  • Tool sub type: Primary antibody
  • Class: Monoclonal
  • Conjugation: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: ChIP ; IHC ; IF ; IP ; WB
  • Description: Small ubiquitin-like modifiers (SUMO) post-translationally modify proteins by a process called SUMOylation. There are three SUMO proteins expressed in vertebrates, SUMO-2 and SUMO-3 are ~95% identical to each other (SUMO-2/3), but they are only ~45% identical to SUMO-1. Consequently, SUMO-2/3 have unique targets and functions compared to SUMO-1. For instances SUMO-2/3 can form polymeric chains and SUMO-1 cannot. SUMOylation on lysine residues regulates various cellular processes including nuclear transport, DNA replication and repair, transcription, protein stability, mitochondrial fission, signal transduction, mitosis and apoptosis.
  • Immunogen: Full length human recombinant protein of SUMO-2
  • Isotype: IgG

Target Details

  • Target: SUMO-2 and SUMO-3 but does not recognize SUMO-1
  • Target background: Small ubiquitin-like modifiers (SUMO) post-translationally modify proteins by a process called SUMOylation. There are three SUMO proteins expressed in vertebrates, SUMO-2 and SUMO-3 are ~95% identical to each other (SUMO-2/3), but they are only ~45% identical to SUMO-1. Consequently, SUMO-2/3 have unique targets and functions compared to SUMO-1. For instances SUMO-2/3 can form polymeric chains and SUMO-1 cannot. SUMOylation on lysine residues regulates various cellular processes including nuclear transport, DNA replication and repair, transcription, protein stability, mitochondrial fission, signal transduction, mitosis and apoptosis.

Applications

  • Application: ChIP ; IHC ; IF ; IP ; WB

Handling

  • Format: Liquid
  • Unit size: 100 ug
  • Storage conditions: -20° C
  • Shipping conditions: Shipping at 4° C

References

  • Zhang et al. 2008. Mol Cell. 29(6):729-41. PMID: 18374647.
  • SUMO-2/3 modification and binding regulate the association of CENP-E with kinetochores and progression through mitosis.