Small ubiquitin-like modifiers (SUMO) post-translationally modify proteins by a process called SUMOylation. There are three SUMO proteins expressed in vertebrates, SUMO-2 and SUMO-3 are ~95% identical to each other (SUMO-2/3), but they are only ~45% identical to SUMO-1. Consequently, SUMO-2/3 have unique targets and functions compared to SUMO-1. For instances SUMO-2/3 can form polymeric chains […]
| Inventor | Institute |
|---|---|
| Michael Matunis | Johns Hopkins University |
| Cat. #: | 153986 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Apoptosis and autophagy;Biochemistry;Cell biology;Cell signaling and signal transduction;Genetics |
| Application: | ChIP ; IHC ; IF ; IP ; WB |
| Target: | SUMO-2 and SUMO-3 but does not recognize SUMO-1 |
| Reactivity: | Human |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | Small ubiquitin-related modifier 2; HSMT3; SMT3 homolog 2; SUMO-3; Zentrin-2; Ubiquitin-like protein SMT3B; Smt3B |
|---|---|
| Product description: | Small ubiquitin-like modifiers (SUMO) post-translationally modify proteins by a process called SUMOylation. There are three SUMO proteins expressed in vertebrates, SUMO-2 and SUMO-3 are ~95% identical to each other (SUMO-2/3), but they are only ~45% identical to SUMO-1. Consequently, SUMO-2/3 have unique targets and functions compared to SUMO-1. For instances SUMO-2/3 can form polymeric chains and SUMO-1 cannot. SUMOylation on lysine residues regulates various cellular processes including nuclear transport, DNA replication and repair, transcription, protein stability, mitochondrial fission, signal transduction, mitosis and apoptosis. |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Immunogen: | Full length human recombinant protein of SUMO-2 |
| Target background: | Small ubiquitin-like modifiers (SUMO) post-translationally modify proteins by a process called SUMOylation. There are three SUMO proteins expressed in vertebrates, SUMO-2 and SUMO-3 are ~95% identical to each other (SUMO-2/3), but they are only ~45% identical to SUMO-1. Consequently, SUMO-2/3 have unique targets and functions compared to SUMO-1. For instances SUMO-2/3 can form polymeric chains and SUMO-1 cannot. SUMOylation on lysine residues regulates various cellular processes including nuclear transport, DNA replication and repair, transcription, protein stability, mitochondrial fission, signal transduction, mitosis and apoptosis. |
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| Format: | Liquid |
|---|---|
| Storage conditions: | -20° C |
| Shipping conditions: | Dry ice |
| References: |
Zhang et al. 2008. Mol Cell. 29(6):729-41. PMID: 18374647. SUMO-2/3 modification and binding regulate the association of CENP-E with kinetochores and progression through mitosis. |
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