Cat. #162379
Anti-Pes1 monoclonal antibody [PES1 8E9]
Cat. #: 162379
Sub-type: Primary antibody
Target: Human Pescadillo Ribosomal Biogenesis Factor 1 (Pes1)
Class: Monoclonal
Application: WB, IP
Reactivity: Human
Host: Rat
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Institute: Helmholtz Munich Core Facility Monoclonal Antibodies
Primary Citation: Holzel et al. 2005. J. Cell Biol. 170: 367-378. PMID: 16043514
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-Pes1 monoclonal antibody [PES1 8E9]
- Alternate name: Anti human Pescadillo Ribosomal Biogenesis Factor 1 (Pes1) monoclonal antibody (clone PES1 8E9)
- Cancer: Breast cancer;Head and neck cancer;Liver cancer
- Research fields: Cancer;Cell biology
- Clone: PES1 8E9
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Reactivity: Human
- Host: Rat
- Disease: Cancer
- Application: WB, IP
- Description: Antibody for PES1, also known as Pescadillo Ribosomal Biogenesis Factor 1, a protein coding gene. PES1 encodes a nuclear protein containing a breast cancer associated gene 1 (BRCA1) C-terminal interaction domain. The encoded protein interacts with BOP1 and WDR12 to form the PeBoW complex, which plays a critical role in cell proliferation via pre-rRNA processing and 60S ribosomal subunit maturation. PES1 has been implicated in multiple cancer types including breast cancer, head and neck cancer, liver cancer and others.
- Immunogen: Ovalbumin coupled to AGSEKEEEARLAALEEQRMEGK peptide
- Isotype: IgG1
Target Details
- Target: Human Pescadillo Ribosomal Biogenesis Factor 1 (Pes1)
- Target alternate names: PES, NOP7
- Target background: Pescadillo Ribosomal Biogenesis Factor 1encodes a nuclear protein that contains a breast cancer associated gene 1 (BRCA1) C-terminal interaction domain. The encoded protein interacts with BOP1 and WDR12 to form the PeBoW complex, which plays a critical role in cell proliferation via pre-rRNA processing and 60S ribosomal subunit maturation. Expression of this gene may play an important role in breast cancer proliferation and tumorigenicity.
Applications
- Application: WB, IP
References
- Holzel et al. 2005. J. Cell Biol. 170: 367-378. PMID: 16043514
