#151620

Anti-MMP3 [1B4]

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Cat. #151620

Anti-MMP3 [1B4]

Cat. #: 151620

Sub-type: Primary antibody

Unit size: 100 ug

Availability: 3-4 weeks

Target: Human matrix metalloproteinase 3 (MMP-3)

Class: Monoclonal

Application: ELISA ; IHC ; IF ; IP ; WB

Reactivity: Human

Host: Mouse

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Ayham Alnabulsi

Institute: Vertebrate Antibodies Limited

Tool Details
Target Details
Applications
Handling
References

Tool Details

*FOR RESEARCH USE ONLY

  • Name: Anti-MMP3 [1B4]
  • Research fields: Cancer;Cell biology;Genetics;Tissue-specific biology
  • Clone: 1B4
  • Tool sub type: Primary antibody
  • Class: Monoclonal
  • Conjugation: Unconjugated
  • Strain: Balb/c
  • Reactivity: Human
  • Host: Mouse
  • Application: ELISA ; IHC ; IF ; IP ; WB
  • Description: Human matrix metalloproteinase 3 (MMP-3) is a member of the matrix metalloproteinases (MMP) family that are peptidases involved in the breakdown of extracellular matrix proteins. MMP-3 degrades fibronectin, laminin, gelatins of type I, III, IV, and V; collagen of type II, III, IV, X, and IX, and proteoglycans. In addition, MMP-3 can also activate other MMPs such as MMP-1, MMP-7, and MMP-9, rendering MMP-3 crucial in connective tissue remodeling. The enzyme is also thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation.
  • Immunogen: Ovalbumin-conjugated synthetic peptide; CKSLRKLEPELH
  • Isotype: IgG1
  • Myeloma used: P3X63Ag8.653
  • Recommended controls: IHC: formalin-fixed, paraffin-embedded lung containing intra-alveolar macrophageswestern blot: rhMMP-3, 400 ng per lane

Target Details

  • Target: Human matrix metalloproteinase 3 (MMP-3)
  • Tissue cell line specificity: IHC: formalin-fixed, paraffin-embedded lung containing intra-alveolar macrophageswestern blot: rhMMP-3, 400 ng per lane
  • Target background: Human matrix metalloproteinase 3 (MMP-3) is a member of the matrix metalloproteinases (MMP) family that are peptidases involved in the breakdown of extracellular matrix proteins. MMP-3 degrades fibronectin, laminin, gelatins of type I, III, IV, and V; collagen of type II, III, IV, X, and IX, and proteoglycans. In addition, MMP-3 can also activate other MMPs such as MMP-1, MMP-7, and MMP-9, rendering MMP-3 crucial in connective tissue remodeling. The enzyme is also thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation.

Applications

  • Application: ELISA ; IHC ; IF ; IP ; WB

Handling

  • Format: Liquid
  • Unit size: 100 ug
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -80° C
  • Shipping conditions: Shipping at 4° C

References

  • Jeffery et al. 2009. Histopathology. 54(7):820-8. PMID: 19635101.
  • The matrix metalloproteinase/tissue inhibitor of matrix metalloproteinase profile in colorectal polyp cancers.
  • Lyall et al. 2006. Clin Cancer Res. 12(4):1184-91. PMID: 16489072.
  • Profiling markers of prognosis in colorectal cancer.
  • Curran et al. 2004. Clin Cancer Res. 10(24):8229-34. PMID: 15623598.
  • Matrix metalloproteinase/tissue inhibitors of matrix metalloproteinase phenotype identifies poor prognosis colorectal cancers.
  • Murray et al. 1998. Gut. 43(6):791-7. PMID: 9824606.
  • Matrix metalloproteinases and their inhibitors in gastric cancer.
  • Murray et al. 1998. J Pathol. 185(3):256-61. PMID: 9771478.
  • Matrix metalloproteinase-1 is associated with poor prognosis in oesophageal cancer.