Cat. #151620
Anti-MMP3 [1B4]
Cat. #: 151620
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 3-4 weeks
Target: Human matrix metalloproteinase 3 (MMP-3)
Class: Monoclonal
Application: ELISA ; IHC ; IF ; IP ; WB
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Ayham Alnabulsi
Institute: Vertebrate Antibodies Limited
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-MMP3 [1B4]
- Research fields: Cancer;Cell biology;Genetics;Tissue-specific biology
- Clone: 1B4
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Strain: Balb/c
- Reactivity: Human
- Host: Mouse
- Application: ELISA ; IHC ; IF ; IP ; WB
- Description: Human matrix metalloproteinase 3 (MMP-3) is a member of the matrix metalloproteinases (MMP) family that are peptidases involved in the breakdown of extracellular matrix proteins. MMP-3 degrades fibronectin, laminin, gelatins of type I, III, IV, and V; collagen of type II, III, IV, X, and IX, and proteoglycans. In addition, MMP-3 can also activate other MMPs such as MMP-1, MMP-7, and MMP-9, rendering MMP-3 crucial in connective tissue remodeling. The enzyme is also thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation.
- Immunogen: Ovalbumin-conjugated synthetic peptide; CKSLRKLEPELH
- Isotype: IgG1
- Myeloma used: P3X63Ag8.653
- Recommended controls: IHC: formalin-fixed, paraffin-embedded lung containing intra-alveolar macrophageswestern blot: rhMMP-3, 400 ng per lane
Target Details
- Target: Human matrix metalloproteinase 3 (MMP-3)
- Tissue cell line specificity: IHC: formalin-fixed, paraffin-embedded lung containing intra-alveolar macrophageswestern blot: rhMMP-3, 400 ng per lane
- Target background: Human matrix metalloproteinase 3 (MMP-3) is a member of the matrix metalloproteinases (MMP) family that are peptidases involved in the breakdown of extracellular matrix proteins. MMP-3 degrades fibronectin, laminin, gelatins of type I, III, IV, and V; collagen of type II, III, IV, X, and IX, and proteoglycans. In addition, MMP-3 can also activate other MMPs such as MMP-1, MMP-7, and MMP-9, rendering MMP-3 crucial in connective tissue remodeling. The enzyme is also thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation.
Applications
- Application: ELISA ; IHC ; IF ; IP ; WB
Handling
- Format: Liquid
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -80° C
- Shipping conditions: Shipping at 4° C
References
- Jeffery et al. 2009. Histopathology. 54(7):820-8. PMID: 19635101.
- The matrix metalloproteinase/tissue inhibitor of matrix metalloproteinase profile in colorectal polyp cancers.
- Lyall et al. 2006. Clin Cancer Res. 12(4):1184-91. PMID: 16489072.
- Profiling markers of prognosis in colorectal cancer.
- Curran et al. 2004. Clin Cancer Res. 10(24):8229-34. PMID: 15623598.
- Matrix metalloproteinase/tissue inhibitors of matrix metalloproteinase phenotype identifies poor prognosis colorectal cancers.
- Murray et al. 1998. Gut. 43(6):791-7. PMID: 9824606.
- Matrix metalloproteinases and their inhibitors in gastric cancer.
- Murray et al. 1998. J Pathol. 185(3):256-61. PMID: 9771478.
- Matrix metalloproteinase-1 is associated with poor prognosis in oesophageal cancer.
