CD5 is a good immunohistochemical marker for T-cells, although not as sensitive as CD3: it was used as a T-cell marker until monoclonal antibodies against CD3 were developed (see our UCHT1 anti-CD3 antibody).
| Inventor | Institute |
|---|---|
| Walter Bodmer | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| Cat. #: | 151103 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Immunology;Stem cell biology |
| Application: | IHC ; IF ; IP ; RIA ; WB |
| Target: | Leu1 (CD5) |
| Reactivity: | Human |
| Clone: | H65 |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | CD5 Molecule 2; Lymphocyte Antigen T1/Leu-1; LEU1; CD5 Antigen; T1 |
|---|---|
| Product description: | CD5 is a good immunohistochemical marker for T-cells, although not as sensitive as CD3: it was used as a T-cell marker until monoclonal antibodies against CD3 were developed (see our UCHT1 anti-CD3 antibody). It is found in 76% of T-cells neoplasms, but also in diffuse large B cell lymphoma, chronic lymphocytic leukemia, hairy cell leukemia, and mantle cell lymphoma cells. It is commonly lost in cutaneous T-cell lymphoma, and its absence can be used as an indicator of malignancy in this condition. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Immunogen: | HSB-2 cells. |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Target background: | CD5 is a good immunohistochemical marker for T-cells, although not as sensitive as CD3: it was used as a T-cell marker until monoclonal antibodies against CD3 were developed (see our UCHT1 anti-CD3 antibody). It is found in 76% of T-cells neoplasms, but also in diffuse large B cell lymphoma, chronic lymphocytic leukemia, hairy cell leukemia, and mantle cell lymphoma cells. It is commonly lost in cutaneous T-cell lymphoma, and its absence can be used as an indicator of malignancy in this condition. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
1st International Workshop on Human Leucocyte Differentiation Antigens (CodeT34) Paris. 1982. |
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