Monoclonal antibody which binds keratin 7.
| Inventor | Institute |
|---|---|
| Birgit Lane | Queen Mary University of London |
| Cat. #: | 151124 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell signaling and signal transduction |
| Application: | IHC ; IF ; WB |
| Target: | Keratin 7 |
| Reactivity: | Mammalian ; Xenopus laevis |
| Clone: | LP1K |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | Monoclonal antibody which binds keratin 7. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Molecular weight: | 54 kDa |
| Immunogen: | Sonicated cytoskeleton fractions (insoluble in 1% Nonidet-P40) from SV40 transformed neonatal keratinocytes. |
| Immunogen Uniprot ID: | P08729 |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratins 7 and 8 are two closely related type II keratins characteristic of simple epithelia. Keratin 7 is less widespread than keratin 8 and is expressed in sebaceous and sweat glands, blood vessels and some cells of the inner hair root sheath. Keratin 7 is often co-expressed with keratin 19. LP1K has some weak reactivity with keratin 8 and other type II keratins. |
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| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | Store at -20° C frozen. Avoid repeated freeze / thaw cycles |
| Shipping conditions: | Dry ice |
| References: |
Lane EB et al. 1985. Ann. NY Acad. Sci. 455:241-58.PMID: 2417515 Reyes et al. 2018. J Oral Microbiol. 10(1):1374153. PMID: 29291034. Yougbar et al. 2017. Nat Commun. 8(1):224. PMID: 28794456. Devos et al. 2017. J Invest Dermatol. 137(2):494-505. PMID: 27725202. Zhang et al. 2015. Reproduction. 150(2):139-49. PMID: 26021998. Zhang et al. 2013. Cell Death Dis. 4:e502. PMID: 23429288. CUL1 promotes trophoblast cell invasion at the maternal-fetal interface. Zhang et al. 2012. PLoS One. 7(6):e38487. PMID: 22679510. Expression of CD82 in human trophoblast and its role in trophoblast invasion. Markey et al. 1992. Br J Dermatol. 126(2):154-60. PMID: 1371396. Keratin expression in basal cell carcinomas. |
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