#151036

Anti-ICAM1 [15.2]

Cat. #151036

Anti-ICAM1 [15.2]

Cat. #: 151036

Sub-type: Primary antibody

Unit size: 100 ug

Availability: 1-2 weeks

Target: ICAM1 (CD54)

Class: Monoclonal

Application: FACS ; IHC ; IP ; Fn

Reactivity: Human

Host: Mouse

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Nancy Hogg

Institute: Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details
Target Details
Applications
Handling
References

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

  • Name: Anti-ICAM1 [15.2]
  • Alternate name: Intercellular Adhesion Molecule 1; Major Group Rhinovirus Receptor; ICAM-1; Cell Surface Glycoprotein P3.58; Human Rhinovirus Receptor; P3.58; CD54; BB2
  • Research fields: Cell biology;Immunology;Stem cell biology;Tissue-specific biology
  • Clone: 15.2
  • Tool sub type: Primary antibody
  • Class: Monoclonal
  • Conjugation: Unconjugated
  • Molecular weight: 85-115 kDa
  • Strain: Balb/c
  • Reactivity: Human
  • Host: Mouse
  • Application: FACS ; IHC ; IP ; Fn
  • Description: ICAMs are members of the immunoglobulin superfamily that is characterised by the presence of immunoglobulin-like domains. ICAM-1 is expressed in haemopoietic cells and vascular endothelium. Cytokine activation causes ICAM-1 expression in other cell types such as fibroblasts and keratinocytes. ICAM-1 is involved in leukocyte recruitment and inflammation. ICAM-1 binds LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18).
  • Immunogen: Rheumatoid synovial cells and human monocytes.
  • Isotype: IgG1
  • Myeloma used: Sp2/0-Ag14
  • Recommended controls: Tonsil

Target Details

  • Target: ICAM1 (CD54)
  • Molecular weight: 85-115 kDa
  • Tissue cell line specificity: Tonsil
  • Target background: ICAMs are members of the immunoglobulin superfamily that is characterised by the presence of immunoglobulin-like domains. ICAM-1 is expressed in haemopoietic cells and vascular endothelium. Cytokine activation causes ICAM-1 expression in other cell types such as fibroblasts and keratinocytes. ICAM-1 is involved in leukocyte recruitment and inflammation. ICAM-1 binds LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18).

Applications

  • Application: FACS ; IHC ; IP ; Fn

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Unit size: 100 ug
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -20° C
  • Shipping conditions: Shipping at 4° C

References

  • Vsquez et al. 2016. Microbes Infect. :. PMID: 27717894.
  • Plasmodium falciparum isolates from patients with uncomplicated malaria promote endothelial inflammation.
  • Intercellular adhesion molecule 1 serves as a primary cognate receptor for the Type IV pilus of nontypeable Haemophilus influenzae.
  • Novotny et al. 2016. Cell Microbiol. :. PMID: 26857242.
  • Perturbation of adhesion molecule-mediated chondrocyte-matrix interactions by 4-hydroxynonenal binding: implication in osteoarthritis pathogenesis.
  • El-Bikai et al. 2010. Arthritis Res Ther. 12(5):R201. PMID: 20977750.
  • Conway et al. 2010. Am J Physiol Heart Circ Physiol. 298(2):H367-74. PMID: 19915176.
  • Endothelial cell responses to atheroprone flow are driven by two separate flow components: low time-average shear stress and fluid flow reversal.
  • Lauriello et al. 2005. Acta Otorhinolaryngol Ital. 25(5):284-91. PMID: 16602327.
  • A two-year course of specific immunotherapy or of continuous antihistamine treatment reverse eosinophilic inflammation in severe persistent allergic rhinitis.
  • Stanley et al. 2000. Biochem J. 351(Pt 1):79-86. PMID: 10998349.
  • The second domain of intercellular adhesion molecule-1 (ICAM-1) maintains the structural integrity of the leucocyte function-associated antigen-1 (LFA-1) ligand-binding site in the first domain.
  • Dransfield et al. 1992. J Cell Biol. 116(6):1527-35. PMID: 1541641.
  • Interaction of leukocyte integrins with ligand is necessary but not sufficient for function.