Anti-integrin a2 [P4B4]

Integrin ?2 is responsible for adhesion of platelets and other cells to collagens. Modulation of collagen and collagenase gene expression force generation and organization of newly synthesized extracellular matrix

Contributors

Inventor Institute
Elizabeth A. Wayner Fred Hutchinson Cancer Center
Cat. #: 161653
Tool sub type: Primary antibody
Research Fields: Cell biology
Application: Western Blotting, Immunoprecipitation, immunofluorescence
Target: Integrin alpha 2
Reactivity: Human
Clone: P4B4
Host: Mouse
Class: Monoclonal
Primary citation: Wayner et al.1987. Journal of Cell Biology.105(4):1873-84. PMID: 2822727
Product description: Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. Integrin ?2 (P4B4) is a mouse monoclonal antibody raised against HT-1080. MoAb developed to identify four distinct classes (I, II, III, IV) of cell surface receptors for native native collagen. P4B4 had an hinhibitory effect on cell adhesion.
Isotype: IgG1
Molecular weight: 150kDa
Immunogen: HT1080 human fibrosarcoma cell line
Target background: CD44 is a hyaluronan cell adhesion molecule (HCAM), GP90 lymphocyte homing receptor, and class III collagen receptor (CRIII). Antibody bound and inhibited cell adhesion to type VI and I collagens (and bound type III, IV, and V collagens with no inhibition) only and not to fibronectin or laminin
Storage conditions: Store at 4° C, **DO NOT FREEZE**. Stable for one year from the date of shipment. Non-hazardous. No MSDS required
Shipping conditions: Dry ice
References:

Wayner et al.1987. Journal of Cell Biology.105(4):1873-84.PMID: 2822727

Symington et al. 1993.J Cell Biol.120(2):523-35.PMID: 8421064

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