Cat. #153311
Anti-IgNAR [V39]
Cat. #: 153311
Unit size: 100 ug
Availability: 3-4 weeks
Target: IgNAR immunoglobulin heavy chain membrane and secretory forms
Class: Monoclonal
Application: ELISA ; WB
Reactivity: Small-spotted catshark
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Ayham Alnabulsi
Institute: Vertebrate Antibodies Limited
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-IgNAR [V39]
- Alternate name: Small-spotted catshark IgNAR, IgNAR antibody, Nanobody, Single domain antibody
- Clone: V39
- Class: Monoclonal
- Conjugation: Unconjugated
- Strain: Balb/c
- Reactivity: Small-spotted catshark
- Host: Mouse
- Application: ELISA ; WB
- Description: Sharks, and other members in Chondrichthyes, produce, apart from the expected IgM and IgW, a type of ancestral antibody referred to immunoglobulin new antigen receptor (IgNAR). IgNAR antibody is composed of only a homodimeric heavy chain which contains one variable and five constant domains for each chain. The distinct structure of IgNAR domains leads to extremely high stability. In addition, VNAR is around 10 times smaller than standard antibodies and able to continue to function and exist within very extreme conditions. These properties allow IgNAR to penetrate tissues easier in vivo to improve bioavailability for pharmaceutical applications. Anti-IgNAR antibody (V39) can be used to monitor IgNAR levels in shark following immunization
- Immunogen: Ovalbumin-conjugated short synthetic peptide
- Isotype: IgG1 kappa
- Myeloma used: P3X63Ag8.653
- Recommended controls: Western Blot, sera
Target Details
- Target: IgNAR immunoglobulin heavy chain membrane and secretory forms
- Target background: Sharks, and other members in Chondrichthyes, produce, apart from the expected IgM and IgW, a type of ancestral antibody referred to immunoglobulin new antigen receptor (IgNAR). IgNAR antibody is composed of only a homodimeric heavy chain which contains one variable and five constant domains for each chain. The distinct structure of IgNAR domains leads to extremely high stability. In addition, VNAR is around 10 times smaller than standard antibodies and able to continue to function and exist within very extreme conditions. These properties allow IgNAR to penetrate tissues easier in vivo to improve bioavailability for pharmaceutical applications. Anti-IgNAR antibody (V39) can be used to monitor IgNAR levels in shark following immunization
Applications
- Application: ELISA ; WB
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Shipping at 4° C
