Human Leukocyte Antigens (HLA) are highly polymorphic proteins that are involved in the presentation of antigens to the T-cell receptor. There are two classes of HLA antigens, class I (HLA-A, HLA-B and HLA-C) and class II (HLA-D). TAL 3C3 may be used for tissue typing on lymphoblastoid cells, transplantation typing, disease susceptibility and detection of class II products.
| Inventor | Institute |
|---|---|
| Julia Bodmer | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| Cat. #: | 152929 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Immunology |
| Application: | IHC ; RIA ; WB |
| Target: | HLA DP alpha (DQ to a lesser extent) |
| Reactivity: | Human |
| Clone: | TAL3C3 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | Human Leukocyte Antigens (HLA) are highly polymorphic proteins that are involved in the presentation of antigens to the T-cell receptor. There are two classes of HLA antigens, class I (HLA-A, HLA-B and HLA-C) and class II (HLA-D). TAL 3C3 may be used for tissue typing on lymphoblastoid cells, transplantation typing, disease susceptibility and detection of class II products. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Molecular weight: | 33 kDa |
| Immunogen: | Bristol 8 separated alpha chain preparation |
| Myeloma used: | P3/NS1/1-Ag4-1 |
| Target background: | Human Leukocyte Antigens (HLA) are highly polymorphic proteins that are involved in the presentation of antigens to the T-cell receptor. There are two classes of HLA antigens, class I (HLA-A, HLA-B and HLA-C) and class II (HLA-D). TAL 3C3 may be used for tissue typing on lymphoblastoid cells, transplantation typing, disease susceptibility and detection of class II products. |
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| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Thomas et al. 1988. J Pathol. 154(4):353-63. PMID: 2455029. HLA-D region alpha-chain monoclonal antibodies: cross-reaction between an anti-DP alpha-chain antibody and smooth muscle. Adams et al. 1983. Immunology. 50(4):613-24. PMID: 6197354. Production and characterization of monoclonal antibodies recognizing the alpha-chain subunits of human ia alloantigens. |
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