Cat. #151876
Anti-FANCM [M40-P2C6]
Cat. #: 151876
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 3-5 days
Target: Fanconi Anemia, Complementation Group M (FANC-M)
Class: Monoclonal
Application: ELISA ; IF ; WB
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Ayham Alnabulsi
Institute: Vertebrate Antibodies Limited
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-FANCM [M40-P2C6]
- Alternate name: Fanconi Anemia Complementation Group M; KIAA1596; Fanconi Anemia-Associated Polypeptide Of 25 Kda; ATP-Dependent RNA Helicase FANCM; Protein Hef Ortholog; FAAP25
- Research fields: Genetics
- Clone: M40-P2C6
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Strain: Balb/c
- Reactivity: Human
- Host: Mouse
- Application: ELISA ; IF ; WB
- Description: Fanconi Anemia, Complementation Group M (FANC-M) is an ATPase required for FANCD2 ubiquitination, a key reaction in DNA repair that binds to ssDNA but not to dsDNA. Mutations in the FANCM are associated with Fanconi anemia, a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. Mutations in the Fanconi anemia DNA repair pathway have been implicated in familial breast cancer risk.
- Immunogen: Peptide Sequence - MLPNDLNQDR (amino acids 2069 -2078)
- Isotype: IgG1 kappa
- Myeloma used: P3X63Ag8.653
- Recommended controls: ELISA- Peptide immunogenWestern Blot- Hela membrane cell extractIF- Hela cells
Target Details
- Target: Fanconi Anemia, Complementation Group M (FANC-M)
- Tissue cell line specificity: ELISA- Peptide immunogenWestern Blot- Hela membrane cell extractIF- Hela cells
- Target background: Fanconi Anemia, Complementation Group M (FANC-M) is an ATPase required for FANCD2 ubiquitination, a key reaction in DNA repair that binds to ssDNA but not to dsDNA. Mutations in the FANCM are associated with Fanconi anemia, a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. Mutations in the Fanconi anemia DNA repair pathway have been implicated in familial breast cancer risk.
Applications
- Application: ELISA ; IF ; WB
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Shipping at 4° C
