#157802

Anti-DNA [m17-s145]

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Cat. #157802

Anti-DNA [m17-s145]

Cat. #: 157802

Unit size: 100 ug

Target: ssDNA and/or dsDNA

Class: Monoclonal

Application: ELISA

Host: Mouse

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Tony Marion

Institute: The University of Tennessee Health Science Center (UTHSC)

Tool Details
Target Details
Applications
Handling
References

Tool Details

*FOR RESEARCH USE ONLY

  • Name: Anti-DNA [m17-s145]
  • Research fields: Immunology
  • Class: Monoclonal
  • Conjugation: Unconjugated
  • Host: Mouse
  • Application: ELISA
  • Description: Monoclonal anti-DNA antibodies were generated from a spontaneous mouse model of Systemic Lupus Erythematosus (SLE) (NZB x NZW)F1 using standard methodologies for the generation of B-cell hybridomas. The mice spontaneously developed anti-DNA antibodies that contributed to SLE disease. The mice were neither immunized nor stimulated non-specifically. Hybridomas derived from these autoimmune mice provide the opportunity to analyse the structure, function, and biology of autoantibodies important to understanding their contribution to the pathogenesis of SLE. Table 1 provides a summary of the variable region structures and DNA specificity for the monoclonal anti-DNA autoantibodies generated.
  • Immunogen uniprot id: N/A
  • Isotype: IgG2b

Target Details

  • Target: ssDNA and/or dsDNA
  • Target background: Monoclonal anti-DNA antibodies were generated from a spontaneous mouse model of Systemic Lupus Erythematosus (SLE) (NZB x NZW)F1 using standard methodologies for the generation of B-cell hybridomas. The mice spontaneously developed anti-DNA antibodies that contributed to SLE disease. The mice were neither immunized nor stimulated non-specifically. Hybridomas derived from these autoimmune mice provide the opportunity to analyse the structure, function, and biology of autoantibodies important to understanding their contribution to the pathogenesis of SLE. Table 1 provides a summary of the variable region structures and DNA specificity for the monoclonal anti-DNA autoantibodies generated.

Applications

  • Application: ELISA

Handling

  • Format: Liquid
  • Unit size: 100 ug
  • Shipping conditions: Shipping at 4° C

References

  • Marion et al. 1997. Methods. 11(1):3-11. PMID: 8990083.
  • Tillman et al. 1992. J Exp Med. 176(3):761-79. PMID: 1512540.
  • Marion et al. 1982. J Immunol. 128(2):668-74. PMID: 7198664.