Anti-DJ-1 [E2-1A]

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

• Name: Anti-DJ-1 [E2-1A]
• Alternate name: PARK7
• Research fields: Apoptosis and autophagy;Cancer;Neurobiology
• Tool sub type: Primary antibody
• Class: Monoclonal
• Conjugation: Unconjugated
• Molecular weight: 24 kDa
• Reactivity: Human
• Host: Mouse
• Application: IHC ; WB
• Description: DJ-1 is a broadly conserved protein among both prokaryotic and eukaryotic cells. It has been identified as playing a diverse role in a range of cellular processes. DJ-1 was originally proposed to be a pro-oncogene, and has since been shown to be expressed at varying levels in breast, non-small cell lung and prostate cancer. It has been demonstrated to paly a role in the regulation of RNA-binding proteins as well as the regulation of testicular androgen receptors and fertilization. In addition, mutations in DJ-1 have been linked to autosomal recessive early-onset familial Parkinson's disease, and have been shown to be a key component of the oxidative stress and ubiquitin-proteasome system response (see Hod, 2004 PMID: 15258905 for additional details).
• Immunogen: Full length recombinant human DJ-1
• Isotype: IgM

Target Details

• Target: DJ-1
• Molecular weight: 24 kDa
• Target background: DJ-1 is a broadly conserved protein among both prokaryotic and eukaryotic cells. It has been identified as playing a diverse role in a range of cellular processes. DJ-1 was originally proposed to be a pro-oncogene, and has since been shown to be expressed at varying levels in breast, non-small cell lung and prostate cancer. It has been demonstrated to paly a role in the regulation of RNA-binding proteins as well as the regulation of testicular androgen receptors and fertilization. In addition, mutations in DJ-1 have been linked to autosomal recessive early-onset familial Parkinson's disease, and have been shown to be a key component of the oxidative stress and ubiquitin-proteasome system response (see Hod, 2004 PMID: 15258905 for additional details).

Applications

• Application: IHC ; WB

Handling

• Format: Liquid
• Unit size: 100 ug
• Shipping conditions: Dry ice

References

• Hod et al. 2004. J Cell Biochem. 92(6):1221-33. PMID: 15258905.
• Hod et al. 1999. J Cell Biochem. 72(3):435-44. PMID: 10022524.