Cyclins bind to and regulate the activity of the Cyclin Dependent Protein Kinases (CDKs). Cyclin A2 is found in proliferating somatic cells and can form complexes with CDK1 and CDK2.
| Inventor | Institute |
|---|---|
| Nancy Hogg | Cancer Research UK, London Research Institute: Clare Hall Laboratories |
| Cat. #: | 151053 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Tissue-specific biology;Cell biology;Genetics |
| Application: | WB |
| Target: | Cyclin A2 |
| Reactivity: | Xenopus laevis |
| Clone: | 46B11 |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | Cyclin A2; Cyclin-A; CCN1; CCNA2 |
|---|---|
| Product description: | Cyclins bind to and regulate the activity of the Cyclin Dependent Protein Kinases (CDKs). Cyclin A2 is found in proliferating somatic cells and can form complexes with CDK1 and CDK2. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Molecular weight: | 160 kDa |
| Immunogen: | SDS derived male Xenopus laevis cyclin A2 fusion protein. |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | Cyclins bind to and regulate the activity of the Cyclin Dependent Protein Kinases (CDKs). Cyclin A2 is found in proliferating somatic cells and can form complexes with CDK1 and CDK2. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 0.88 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Serr et al. 2016. Nat Commun. 7:10991. PMID: 26975663. Type 1 diabetes vaccine candidates promote human Foxp3(+)Treg induction in humanized mice. Wong et al. 2016. Sci Rep. 6:21023. PMID: 26876805. The Role of Physical Stabilization in Whole Blood Preservation. Bock et al. 2016. Pharmacol Res. :. PMID: 26794428. Acute myeloid leukaemia-derived Langerhans-like cells enhance Th1 polarization upon TLR2 engagement. Chen et al. 2016. J Immunol. :. PMID: 26764035. Autoreactive CD19+CD20- Plasma Cells Contribute to Disease Severity of Experimental Autoimmune Encephalomyelitis. Jobe et al. 2015. J Leukoc Biol. :. PMID: 26667473. Effect of cytokines on Siglec-1 and HIV-1 entry in monocyte-derived macrophages: the importance of HIV-1 envelope V1V2 region. Tosh et al. 2015. J Immunol. :. PMID: 26597011. The IL-12 Response of Primary Human Dendritic Cells and Monocytes to Toxoplasma gondii Is Stimulated by Phagocytosis of Live Parasites Rather Than Host Cell Invasion. Phenotypic, Fn, and plasticity features of classical and alternatively activated human macrophages. Sugimoto et al. 2015. J Immunol. 195(4):1774-81. PMID: 26179903. Riise et al. 2015. J Immunol. 195(3):1121-8. PMID: 26085684. Differentiation Kinetics of Blood Monocytes and Dendritic Cells in Macaques: Insights to Understanding Human Myeloid Cell Development. TLR-Stimulated Neutrophils Instruct NK Cells To Trigger Dendritic Cell Maturation and Promote Adaptive T Cell Responses. Tarique et al. 2015. Am J Respir Cell Mol Biol. :. PMID: 25870903. Mohanty et al. 2015. J Infect Dis. 211(7):1174-84. PMID: 25367297. Hong et al. 2015. Nat Commun. 6:6588. PMID: 25807344. Trained immunity in newborn infants of HBV-infected mothers. Prolonged proinflammatory cytokine production in monocytes modulated by interleukin 10 after influenza vaccination in older adults. Thurlow et al. 2010. Infect Immun. 78(11):4936-43. PMID: 20713628. Gelatinase contributes to the pathogenesis of endocarditis caused by Enterococcus faecalis. Stapulionis et al. 2008. J Immunol. 180(6):3946-56. PMID: 18322203. Structural insight into the function of myelin basic protein as a ligand for integrin alpha M beta 2. Malhotra et al. 1986. Eur J Immunol. 16(9):1117-23. PMID: 3530784. Ligand binding by the p150,95 antigen of U937 monocytic cells: properties in common with complement receptor type 3 (CR3). |
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