To5 may be used in studies of immune complex mediated glomerulopathies.
| Inventor | Institute |
|---|---|
| Jacqueline Cordell | University of Oxford |
| Cat. #: | 151360 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Immunology |
| Application: | FACS ; IHC ; IF ; WB |
| Target: | Complement Receptor Type 1 (CR1, CD35) |
| Reactivity: | Human |
| Clone: | To5 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | To5 may be used in studies of immune complex mediated glomerulopathies. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Immunogen: | C3b receptor-enriched precipitates from tonsil cell membranes |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Target background: | CR1 is found on many leucocytes and binds C3b and C4b. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Kremlitzka et al. 2013. Int Immunol. 25(1):25-33. PMID: 22962438. Complement receptor type 1 (CR1, CD35) is a potent inhibitor of B-cell functions in rheumatoid arthritis patients. Gerdes et al. 1982. Immunology. 45(4):645-53. PMID: 7068171. Human complement (C3b) receptors defined by a mouse monoclonal antibody. Fearon et al. 1980. J Exp Med. 152(1):20-30. PMID: 6967510. Identification of the membrane glycoprotein that is the C3b receptor of the human erythrocyte, polymorphonuclear leukocyte, B lymphocyte, and monocyte. Gerdes et al. 1980. Immunology. 39(1):75-84. PMID: 6991397. Xenoantiserum to human C3 receptors: its preparation and effect on the C3b and C3d receptors of tonsil cells and the C3b receptors of erythrocytes and neutrophils. |
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