Cat. #151783
Anti-Codanin1 [Cod177]
Cat. #: 151783
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 3-4 weeks
Target: Codanin
Class: Monoclonal
Application: IF ; WB
Reactivity: Human ; Mouse
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Tasneem Ritchie
Institute: University of Oxford
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-Codanin1 [Cod177]
- Alternate name: Codanin 1; Congenital Dyserythropoietic Anemia; Type I; Discs Lost Homolog; PRO1295; CDAN1A; CDA1; DLT
- Research fields: Tissue-specific biology
- Clone: Cod177
- Tool sub type: Primary antibody
- Class: Monoclonal
- Purpose: Marker
- Conjugation: Unconjugated
- Reactivity: Human ; Mouse
- Host: Mouse
- Application: IF ; WB
- Description: Codanin-1 may act as a negative regulator of histone chaperone anti-silencing function 1 (ASF1) in chromatin assembly. Mutations in the codanin-1 gene cause congenital dyserythropoietic anemia 1 (CDA1), which is an autosomal recessive blood disorder characterised by morphological abnormalities of erythroblasts, ineffective erythropoiesis, macrocytic anemia and secondary hemochromatosis.
- Immunogen: aa 294-607 of cloned human protein
- Isotype: IgG2b
- Myeloma used: NS0
- Recommended controls: HeLa cells
Target Details
- Target: Codanin
- Tissue cell line specificity: Mouse
- Target background: Codanin-1 may act as a negative regulator of histone chaperone anti-silencing function 1 (ASF1) in chromatin assembly. Mutations in the codanin-1 gene cause congenital dyserythropoietic anemia 1 (CDA1), which is an autosomal recessive blood disorder characterised by morphological abnormalities of erythroblasts, ineffective erythropoiesis, macrocytic anemia and secondary hemochromatosis.
Applications
- Application: IF ; WB
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Dry ice
References
- Renella et al. 2011. Blood. 117(25):6928-38. PMID: 21364188.
- Codanin-1 mutations in congenital dyserythropoietic anemia type 1 affect HP1 localization in erythroblasts.
