#151783

Anti-Codanin1 [Cod177]

Cat. #151783

Anti-Codanin1 [Cod177]

Cat. #: 151783

Sub-type: Primary antibody

Unit size: 100 ug

Availability: 3-4 weeks

Target: Codanin

Class: Monoclonal

Application: IF ; WB

Reactivity: Human ; Mouse

Host: Mouse

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Tasneem Ritchie

Institute: University of Oxford

Tool Details
Target Details
Applications
Handling
References

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

  • Name: Anti-Codanin1 [Cod177]
  • Alternate name: Codanin 1; Congenital Dyserythropoietic Anemia; Type I; Discs Lost Homolog; PRO1295; CDAN1A; CDA1; DLT
  • Research fields: Tissue-specific biology
  • Clone: Cod177
  • Tool sub type: Primary antibody
  • Class: Monoclonal
  • Purpose: Marker
  • Conjugation: Unconjugated
  • Reactivity: Human ; Mouse
  • Host: Mouse
  • Application: IF ; WB
  • Description: Codanin-1 may act as a negative regulator of histone chaperone anti-silencing function 1 (ASF1) in chromatin assembly. Mutations in the codanin-1 gene cause congenital dyserythropoietic anemia 1 (CDA1), which is an autosomal recessive blood disorder characterised by morphological abnormalities of erythroblasts, ineffective erythropoiesis, macrocytic anemia and secondary hemochromatosis.
  • Immunogen: aa 294-607 of cloned human protein
  • Isotype: IgG2b
  • Myeloma used: NS0
  • Recommended controls: HeLa cells

Target Details

  • Target: Codanin
  • Tissue cell line specificity: Mouse
  • Target background: Codanin-1 may act as a negative regulator of histone chaperone anti-silencing function 1 (ASF1) in chromatin assembly. Mutations in the codanin-1 gene cause congenital dyserythropoietic anemia 1 (CDA1), which is an autosomal recessive blood disorder characterised by morphological abnormalities of erythroblasts, ineffective erythropoiesis, macrocytic anemia and secondary hemochromatosis.

Applications

  • Application: IF ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Unit size: 100 ug
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15° C to -25° C
  • Shipping conditions: Shipping at 4° C

References

  • Renella et al. 2011. Blood. 117(25):6928-38. PMID: 21364188.
  • Codanin-1 mutations in congenital dyserythropoietic anemia type 1 affect HP1 localization in erythroblasts.