Codanin-1 may act as a negative regulator of histone chaperone anti-silencing function 1 (ASF1) in chromatin assembly. Mutations in the codanin-1 gene cause congenital dyserythropoietic anemia 1 (CDA1), which is an autosomal recessive blood disorder characterised by morphological abnormalities of erythroblasts, ineffective erythropoiesis, macrocytic anemia and secondary hemochromatosis.
| Inventor | Institute |
|---|---|
| Tasneem Ritchie | University of Oxford |
| Cat. #: | 151783 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Tissue-specific biology |
| Application: | IF ; WB |
| Target: | Codanin |
| Reactivity: | Human ; Mouse |
| Clone: | Cod177 |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | Codanin 1; Congenital Dyserythropoietic Anemia; Type I; Discs Lost Homolog; PRO1295; CDAN1A; CDA1; DLT |
|---|---|
| Product description: | Codanin-1 may act as a negative regulator of histone chaperone anti-silencing function 1 (ASF1) in chromatin assembly. Mutations in the codanin-1 gene cause congenital dyserythropoietic anemia 1 (CDA1), which is an autosomal recessive blood disorder characterised by morphological abnormalities of erythroblasts, ineffective erythropoiesis, macrocytic anemia and secondary hemochromatosis. |
| Conjugation: | Unconjugated |
| Isotype: | IgG2b |
| Immunogen: | aa 294-607 of cloned human protein |
| Myeloma used: | NS0 |
| Target background: | Codanin-1 may act as a negative regulator of histone chaperone anti-silencing function 1 (ASF1) in chromatin assembly. Mutations in the codanin-1 gene cause congenital dyserythropoietic anemia 1 (CDA1), which is an autosomal recessive blood disorder characterised by morphological abnormalities of erythroblasts, ineffective erythropoiesis, macrocytic anemia and secondary hemochromatosis. |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Renella et al. 2011. Blood. 117(25):6928-38. PMID: 21364188. Codanin-1 mutations in congenital dyserythropoietic anemia type 1 affect HP1 localization in erythroblasts. |
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