Anti-CD18 [BU87]

The CD18 protein is the integrin beta chain beta 2. Integrins are integral cell-surface proteins composed of alpha and beta chains. A given chain may combine with multiple partners resulting in different integrins. In humans a lack of CD18 causes leukocyte adhesion deficiency, a disease defined by a lack of leukocyte extravasation from blood into […]

Contributors

Inventor Institute
Margaret Goodall University of Birmingham
Cat. #: 153231
Unit size: 100 ug
Research Fields: Cell biology;Cell signaling and signal transduction;Immunology;Stem cell biology
Application: IHC
Target: CD18
Reactivity: Human ; Pig ; Primate
Clone: BU87
Host: Mouse
Class: Monoclonal
Alternate name: Cell differentiation 18; Integrin beta-2; ITGB2 gene
Product description: The CD18 protein is the integrin beta chain beta 2. Integrins are integral cell-surface proteins composed of alpha and beta chains. A given chain may combine with multiple partners resulting in different integrins. In humans a lack of CD18 causes leukocyte adhesion deficiency, a disease defined by a lack of leukocyte extravasation from blood into tissues. The beta 2 integrins have also been found in a soluble form and these ligand binding proteins are inversely associated with disease activity in the autoimmune disease spondyloarthritis.
Conjugation: Unconjugated
Isotype: IgG2a
Target background: The CD18 protein is the integrin beta chain beta 2. Integrins are integral cell-surface proteins composed of alpha and beta chains. A given chain may combine with multiple partners resulting in different integrins. In humans a lack of CD18 causes leukocyte adhesion deficiency, a disease defined by a lack of leukocyte extravasation from blood into tissues. The beta 2 integrins have also been found in a soluble form and these ligand binding proteins are inversely associated with disease activity in the autoimmune disease spondyloarthritis.
Format: Liquid
Concentration: 0.9-1.1mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

10431789: Leucocyte Typing VI, 1998, Kishimoto_T. Garland Publishing, NY.

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