Anti-CD11b (Integrin aM) [ICRF44]

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

• Name: Anti-CD11b (Integrin aM) [ICRF44]
• Alternate name: Integrin Subunit Alpha M; Cell Surface Glycoprotein MAC-1 Subunit Alpha; Complement Component 3 Receptor 3 Subunit; CD11 Antigen-Like Family Member B; Leukocyte Adhesion Receptor MO1; CR-3 Alpha Chain; CD11B; CR3A; Macrophage Antigen Alpha Polypeptide); Neutrophil Adherence Receptor Alpha-M Subunit 3; Macrophage Antigen Alpha Polypeptide 3; Neutrophil Adherence Receptor 4; Antigen CD11b (P17) 3; CD11b Antigen; MAC-1; MAC1A; SLEB6; MO1A
• Research fields: Cell biology
• Clone: ICRF44
• Tool sub type: Primary antibody
• Class: Monoclonal
• Conjugation: Unconjugated
• Molecular weight: 160 kDa
• Strain: Balb/c
• Reactivity: Human ; Primate
• Host: Mouse
• Application: FACS ; IHC ; IP ; WB
• Description: ICRF 44 blocks some functions of Mac-1.
• Immunogen: Rheumatoid synovial cells and human monocytes.
• Isotype: IgG1
• Myeloma used: Sp2/0-Ag14
• Recommended controls: Monocytes or neutrophils

Target Details

• Target: Integrin alpha M (CD11b; Mac-1a subunit)
• Molecular weight: 160 kDa
• Tissue cell line specificity: Monocytes or neutrophils
• Target background: Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha M (CD11B) is found in neutrophils, monocytes and NK cells. Patients lacking integrin aM molecules have immune deficiency symptoms and commonly subject to bacterial and fungal infections.

Applications

• Application: FACS ; IHC ; IP ; WB

Handling

• Format: Liquid
• Concentration: 1 mg/ml
• Unit size: 100 ug
• Storage buffer: PBS with 0.02% azide
• Storage conditions: -15° C to -25° C
• Shipping conditions: Shipping at 4° C

References

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