Anti-CD11b [2LPM19c]

Tool Details

*FOR RESEARCH USE ONLY

• Name: Anti-CD11b [2LPM19c]
• Alternate name: CD11b, Integrin alpha M, Integrin aM, Mac-1 a subunit, C3bi receptor, CD11 antigen-like family member B, CR-3 alpha chain, Cell surface glycoprotein MAC-1 subunit alpha, Leukocyte adhesion receptor MO1, Neutrophil adherence receptor
• Research fields: Apoptosis and autophagy;Cell biology;Cell signaling and signal transduction;Immunology;Neurobiology;Stem cell biology
• Clone: 2LPM19c
• Tool sub type: Primary antibody
• Class: Monoclonal
• Conjugation: Unconjugated
• Molecular weight: 127 kDa
• Reactivity: Human
• Host: Mouse
• Application: FACS ; IHC
• Description: CD11b, also known as Integrin alpha M, is found in neutrophils, monocytes and Natural Killer (NK) cells. CD11b plays a role in chemotaxis, apoptosis and phagocytosis. It is absent in Leukocyte Adhesion Deficiency (LAD-1) and is a target for anti-inflammatory drug therapies. CD11b is part of the CD11b/CD18 heterodimer (Mac-1 a, M?Ÿ2 integrin), also known as the C3 complement receptor. It functions as a receptor for complement (C3bi), fibrinogen, or clotting factor X. In humans, CD11b is strongly expressed on myeloid cells and weakly expressed on NK cells and some activated lymphocytes as well as on microglia in the brain.
• Immunogen: Purified C3bi receptor
• Isotype: IgG1 kappa
• Myeloma used: P3/NS1/1-Ag4.1

Target Details

• Target: Cluster of Differentiation 11b (CD11b)
• Molecular weight: 127 kDa
• Target background: CD11b, also known as Integrin alpha M, is found in neutrophils, monocytes and Natural Killer (NK) cells. CD11b plays a role in chemotaxis, apoptosis and phagocytosis. It is absent in Leukocyte Adhesion Deficiency (LAD-1) and is a target for anti-inflammatory drug therapies. CD11b is part of the CD11b/CD18 heterodimer (Mac-1 a, M?2 integrin), also known as the C3 complement receptor. It functions as a receptor for complement (C3bi), fibrinogen, or clotting factor X. In humans, CD11b is strongly expressed on myeloid cells and weakly expressed on NK cells and some activated lymphocytes as well as on microglia in the brain.

Applications

• Application: FACS ; IHC

Handling

• Format: Liquid
• Concentration: 0.9-1.1 mg/ml
• Unit size: 100 ug
• Storage buffer: PBS with 0.02% azide
• Storage conditions: -15° C to -25° C
• Shipping conditions: Shipping at 4° C

References

• Kupatt et al. 2000. Arterioscler Thromb Vasc Biol. 20(10):2226-32. PMID: 11031208.
• c7E3Fab reduces postischemic leukocyte-thrombocyte interaction mediated by fibrinogen. Implications for myocardial reperfusion injury.
• Violette et al. 1995. J Immunol. 155(6):3092-101. PMID: 7673724.
• Differences in the binding of blocking anti-CD11b monoclonal antibodies to the A-domain of CD11b.
• Diamond et al. 1993. J Cell Biol. 120(4):1031-43. PMID: 7679388.
• The I domain is a major recognition site on the leukocyte integrin Mac-1 (CD11b/CD18) for four distinct adhesion ligands.